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Literature summary for 2.7.7.46 extracted from
- Determination of the rate-limiting segment of aminoglycoside nucleotidyltransferase 2''-I by pH- and viscosity-dependent kinetics (1988), Biochemistry, 27, 3834-3842.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| gentamycin C1 | - |
Escherichia coli |  |
| netilmicin | substrate inhibition | Escherichia coli | |
| sisomicin | uncompetitive substrate inhibition | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + netilmicin C | - |
Escherichia coli | diphosphate + 2''-adenylylnetilmicin C | - |
r | |
| ATP + sisomicin | - |
Escherichia coli | diphosphate + 2''-adenylylsisomicin | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminoglycoside nucleotidyltransferase 2''-I | - |
Escherichia coli |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9.5 | - |
Escherichia coli |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.154 | - |
sisomicin | - |
Escherichia coli | |
| 1.84 | - |
gentamycin C1 | - |
Escherichia coli | |
| 5.12 | - |
netilmicin | - |
Escherichia coli | |
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