Cloned (Comment) | Organism |
---|---|
- |
Neisseria meningitidis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CDP | 1 mM, 37°C, pH 8.5, 15 min, 14% inhibition | Neisseria meningitidis | |
saturated sulfo-CDP | 1 mM, 37°C, pH 8.5, 15 min, 55% inhibition | Neisseria meningitidis | |
saturated sulfo-UDP | 1 mM, 37°C, pH 8.5, 15 min, 35% inhibition | Neisseria meningitidis | |
saturated sulfo-UDP ester | 1 mM, 37°C, pH 8.5, 15 min, 24% inhibition | Neisseria meningitidis | |
sulfo-CDP | 1 mM, 37°C, pH 8.5, 15 min, 47% inhibition | Neisseria meningitidis | |
sulfo-CTP | 1 mM, 37°C, pH 8.5, 15 min, 39% inhibition | Neisseria meningitidis | |
sulfo-UDP | 1 mM, 37°C, pH 8.5, 15 min, 6% inhibition | Neisseria meningitidis | |
sulfo-UTP | 1 mM, 37°C, pH 8.5, 15 min, 33% inhibition | Neisseria meningitidis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Neisseria meningitidis | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + sialic acid | Neisseria meningitidis | - |
CMP-sialic acid + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neisseria meningitidis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Neisseria meningitidis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + sialic acid | - |
Neisseria meningitidis | CMP-sialic acid + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CMP-sialic acid synthetase | - |
Neisseria meningitidis |
CSS | - |
Neisseria meningitidis |
NmCSS | - |
Neisseria meningitidis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
inhibition assay | Neisseria meningitidis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
inhibition assay | Neisseria meningitidis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
1 mM, 37°C, pH 8.5, 15 min, 14% inhibition | Neisseria meningitidis | CDP | |
additional information | - |
1 mM, 37°C, pH 8.5, 15 min, 24% inhibition | Neisseria meningitidis | saturated sulfo-UDP ester | |
additional information | - |
1 mM, 37°C, pH 8.5, 15 min, 33% inhibition | Neisseria meningitidis | sulfo-UTP | |
additional information | - |
1 mM, 37°C, pH 8.5, 15 min, 35% inhibition | Neisseria meningitidis | saturated sulfo-UDP | |
additional information | - |
1 mM, 37°C, pH 8.5, 15 min, 39% inhibition | Neisseria meningitidis | sulfo-CTP | |
additional information | - |
1 mM, 37°C, pH 8.5, 15 min, 47% inhibition | Neisseria meningitidis | sulfo-CDP | |
additional information | - |
1 mM, 37°C, pH 8.5, 15 min, 55% inhibition | Neisseria meningitidis | saturated sulfo-CDP | |
additional information | - |
1 mM, 37°C, pH 8.5, 15 min, 6% inhibition | Neisseria meningitidis | sulfo-UDP |
General Information | Comment | Organism |
---|---|---|
physiological function | CMP-sialic acid synthetase is a key enzyme in the biosynthesis of the capsular polysaccharides required for bacterial infection | Neisseria meningitidis |