Literature summary for 2.7.7.42 extracted from

Jiang, P.; Peliska, J.; Ninfa, A.
The regulation of Escherichia coli glutamine synthetase revisited: Role of 2-ketoglutarate in the regulation of glutamine synthetase adenylylation state (1998), Biochemistry, 37, 12802-12810.

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the bifunctional adenylyltransferase ATase, product of glnE, catalyzes the adenylylation of glutamine synthetase and the deadenylylation of glutamine synthetase-AMP, reaction of EC 2.7.7.89. The adenylylation reaction is activated by PII signal transduction protein, while the deadenylylation reaction requires PII-UMP. Both of these reactions are stimulated by 2-ketoglutarate and ATP	Escherichia coli	?	-	?
[L-glutamate:ammonia ligase (ADP-forming)]-O4-(5'-adenylyl)-L-tyrosine + H2O	-	Escherichia coli	adenylate + [L-glutamate:ammonia ligase (ADP-forming)]-L-tyrosine	-	?

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Release 2023.1 (January 2023)