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Literature summary for 2.7.7.4 extracted from

  • Schroeder, E.; Gebel, L.; Eremeev, A.A.; Morgner, J.; Grum, D.; Knauer, S.K.; Bayer, P.; Mueller, J.W.
    Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm (2012), PLoS ONE, 7, e29559.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
isoform PAPS synthase 1 wild type and mutant proteins are expressed in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isoform PAPSS2 is localised mainly within the cytoplasm Homo sapiens 5737
-
nucleus isoform PAPSS1 is predominantly nuclear Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
133000
-
isoform PAPSS1, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43252 bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
-

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose column chromatography and Superdex 200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the bifunctional PAPS synthases 1 and 2 consist of an N-terminal adenosine-5'-phosphosulphate kinase domain and a C-terminal ATP sulphurylase domain connected by a short irregular linker Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
3'-phospho-adenosine-5'-phosphosulphate synthase
-
Homo sapiens
ATP sulphurylase
-
Homo sapiens
PAPS synthase
-
Homo sapiens
PAPSS1 isoform Homo sapiens
PAPSs2 isoform Homo sapiens