Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-(1-phenyl-1H-indol-3-yl)-2,4-dioxy-5-hexenoic acid | IC50: 0.0472 mM | Bos taurus | |
6-(1-phenylmethyl-1H-indol-3-yl)-2,4-dioxy-5-hexenoic acid | IC50: 0.0079 mM | Bos taurus | |
6-(4-benzoyl-1-phenylmethyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acid | IC50: 0.0162 mM | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNA | Bos taurus | the enzyme has a key role in V(D)J recombination during lymphocyte and repertoire development | diphosphate + DNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukemia cell | more than 90% of leukemic cells in acute lymphocytic leukemia and approximately 30% of leukemic cells in the chronic myelogenous leukemia crisis show elevated TDP activity | Bos taurus | - |
thymus | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNA | the enzyme has a key role in V(D)J recombination during lymphocyte and repertoire development | Bos taurus | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TdT | - |
Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0079 | - |
IC50: 0.0079 mM | Bos taurus | 6-(1-phenylmethyl-1H-indol-3-yl)-2,4-dioxy-5-hexenoic acid | |
0.0162 | - |
IC50: 0.0162 mM | Bos taurus | 6-(4-benzoyl-1-phenylmethyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acid | |
0.0472 | - |
IC50: 0.0472 mM | Bos taurus | 6-(1-phenyl-1H-indol-3-yl)-2,4-dioxy-5-hexenoic acid |