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Literature summary for 2.7.7.3 extracted from

  • Brown, K.L.; Morris, V.K.; Izard, T.
    Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase (2004), Acta Crystallogr. Sect. D, 60, 195-196.
    View publication on PubMed
Search for more literature for 2.7.7.3

Application

Application Comment Organism
drug development potential target for antibiotic drugs Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pantetheine 4'-phosphate Mycobacterium tuberculosis rate-limiting penultimate step in coenzyme A biosynthesis diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate Mycobacterium tuberculosis Rv2965c rate-limiting penultimate step in coenzyme A biosynthesis diphosphate + 3'-dephospho-CoA
-
 r

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis Rv2965c
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pantetheine 4'-phosphate
-
 Mycobacterium tuberculosis diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate rate-limiting penultimate step in coenzyme A biosynthesis Mycobacterium tuberculosis diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate
-
 Mycobacterium tuberculosis Rv2965c diphosphate + 3'-dephospho-CoA
-
 r
ATP + pantetheine 4'-phosphate rate-limiting penultimate step in coenzyme A biosynthesis Mycobacterium tuberculosis Rv2965c diphosphate + 3'-dephospho-CoA
-
 r

Synonyms

Synonyms Comment Organism
More bifunctional enzyme catalyzing the last two steps of coenzyme A biosynthesis Mycobacterium tuberculosis