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Literature summary for 2.7.7.23 extracted from

  • Kostrewa, D.; D'Arcy, A.; Takacs, B.; Kamber, M.
    Crystal structures of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase, GlmU, in apo form at 2.33 A resolution and in complex with UDP-N-acetylglucosamine and Mg(2+) at 1.96 A resolution (2001), J. Mol. Biol., 305, 279-289.
    View publication on PubMed
Search for more literature for 2.7.7.23

Application

Application Comment Organism
medicine potential target for antibacterial agents Streptococcus pneumoniae

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Streptococcus pneumoniae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ cofactor Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diphosphate + UDP-N-acetyl-D-glucosamine Streptococcus pneumoniae amino sugar metabolism UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
diphosphate + UDP-N-acetyl-D-glucosamine Streptococcus pneumoniae involved in synthesis of peptidoglycan and lipopolysaccharide UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae Q97R46
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diphosphate + UDP-N-acetyl-D-glucosamine
-
 Streptococcus pneumoniae UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
diphosphate + UDP-N-acetyl-D-glucosamine amino sugar metabolism Streptococcus pneumoniae UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r
diphosphate + UDP-N-acetyl-D-glucosamine involved in synthesis of peptidoglycan and lipopolysaccharide Streptococcus pneumoniae UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 r

Subunits

Subunits Comment Organism
trimer
-
 Streptococcus pneumoniae

Synonyms

Synonyms Comment Organism
More bifunctional enzyme with activity of: glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase Streptococcus pneumoniae