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Literature summary for 2.7.7.23 extracted from
- Crystal structure of Streptococcus pneumoniae N-acetylglucosamine-1-phosphate uridyltransferase bound to acetyl-coenzyme A reveals a novel active site architecture (2001), J. Biol. Chem., 276, 11844-11851.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | potential target for antibacterial agents | Streptococcus pneumoniae |
| medicine | potential target for antibacterial agents | Escherichia coli |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in M15 cells | Streptococcus pneumoniae |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| recombinant enzyme, hanging drop vapor diffusion method | Streptococcus pneumoniae |
| recombinant enzyme, hanging drop vapor diffusion method | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diphosphate + UDP-N-acetyl-D-glucosamine | Streptococcus pneumoniae | amino sugar metabolism | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r |  |
| diphosphate + UDP-N-acetyl-D-glucosamine | Escherichia coli | amino sugar metabolism | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
| diphosphate + UDP-N-acetyl-D-glucosamine | Streptococcus pneumoniae | involved in synthesis of peptidoglycan and lipopolysaccharide | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
| diphosphate + UDP-N-acetyl-D-glucosamine | Escherichia coli | involved in synthesis of peptidoglycan and lipopolysaccharide | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P0ACC7 | - |
- |
| Streptococcus pneumoniae | Q97R46 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Streptococcus pneumoniae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diphosphate + UDP-N-acetyl-D-glucosamine | - |
Streptococcus pneumoniae | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
| diphosphate + UDP-N-acetyl-D-glucosamine | - |
Escherichia coli | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
| diphosphate + UDP-N-acetyl-D-glucosamine | amino sugar metabolism | Streptococcus pneumoniae | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
| diphosphate + UDP-N-acetyl-D-glucosamine | amino sugar metabolism | Escherichia coli | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
| diphosphate + UDP-N-acetyl-D-glucosamine | involved in synthesis of peptidoglycan and lipopolysaccharide | Streptococcus pneumoniae | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
| diphosphate + UDP-N-acetyl-D-glucosamine | involved in synthesis of peptidoglycan and lipopolysaccharide | Escherichia coli | UTP + N-acetyl-alpha-D-glucosamine 1-phosphate | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | - |
Escherichia coli |
| trimer | crystal structure analysis | Streptococcus pneumoniae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | bifunctional enzyme with activity of: glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase | Streptococcus pneumoniae |
| More | bifunctional enzyme with activity of: glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase | Escherichia coli |
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