Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P51003 | - |
- |
Homo sapiens | Q9BWT3 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
PAPalpha | - |
Homo sapiens |
PAPgamma | - |
Homo sapiens |
PAPOLA | - |
Homo sapiens |
PAPOLG | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | inactivation of PAP-dependent hyperadenylation in cells leads to the upregulation of various ncRNAs, including snoRNA host genes, primary miRNA transcripts, and promoter upstream antisense RNAs. mRNAs with retained introns are susceptible to PABPN1 and PAPalpha/gamma-mediated decay. Transcripts are targeted for degradation due to inefficient export, a consequence of reduced intron number or incomplete splicing. A genetically-encoded poly(A) tail is sufficient to drive decay. Treatment with transcription inhibitors uncouples polyadenylation from decay, leading to runaway hyperadenylation of nuclear decay targets | Homo sapiens |