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Literature summary for 2.7.7.19 extracted from

  • Losh, J.S.; King, A.K.; Bakelar, J.; Taylor, L.; Loomis, J.; Rosenzweig, J.A.; Johnson, S.J.; van Hoof, A.
    Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing (2015), Nucleic Acids Res., 43, 1848-1858.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P48561
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Synonyms

Synonyms Comment Organism
poly(A) RNA polymerase protein 1
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 Saccharomyces cerevisiae
Trf5
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function nuclear RNA-dependent ATPase Mtr4 and either the nuclear non-canonical poly(A) polymerases, Trf4 or Trf5 assemble into a Trf4/5Air1/2/Mtr4 polyadenylation complex TRAMP. Disrupting the Mtr4/Trf interaction disrupts specific TRAMP and exosome functions, including small nucleolar RNA processing. A 20 amino acid peptide, residues 98-117 in the N-terminus of Trf5 is important for TRAMP complex formation Saccharomyces cerevisiae