Literature summary for 2.7.7.19 extracted from

Muniz, L.; Davidson, L.; West, S.
Poly(A) polymerase and the nuclear poly(A) binding protein, PABPN1, coordinate the splicing and degradation of a subset of human pre-mRNAs (2015), Mol. Cell. Biol., 35, 2218-2230.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information

General Information	Comment	Organism
physiological function	a terminal poly(A) tail is important for a subset of intron excision events that follow cleavage and polyadenylation. In these cases, splicing is promoted by the nuclear poly(A) binding protein, PABPN1, and poly(A) polymerase, PAP. Poly(A) polymerase is needed for efficient splicing. Inefficient polyadenylation is associated with impaired recruitment of splicing factors to affected introns, which are consequently degraded by the exosome	Homo sapiens

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Release 2023.1 (January 2023)