Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6PIY7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | primary foreskin fibroblasts | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
germline development 2 | - |
Homo sapiens |
GLD2 | - |
Homo sapiens |
GLD4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | depletion of isoform Gld2 promotes rather than inhibits p53 mRNA polyadenylation/translation, induces premature senescence and enhances the stability of cytoplasmic polyadenylation element binding protein CPEB mRNA. TheCPEB 3' untranslated region contains two miR-122 binding sites, which when deleted, elevate mRNA translation. miR-122 is present in primary fibroblasts and destabilizes by Gld2 depletion | Homo sapiens |
physiological function | isoform GLD4 regulates p53 polyadenylation/translation in a cytoplasmic polyadenylation element binding protein CPEB dependent manner | Homo sapiens |