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Literature summary for 2.7.7.19 extracted from
- ERK is a novel regulatory kinase for poly(A) polymerase (2008), Nucleic Acids Res., 36, 803-813.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | PAP phosphorylation of serine 537 by extracellular signal-regulated kinase increases its nonspecific polyadenylation activity | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HeLa cells and in Escherichia coli | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S537A | the mutant catalytic domain is not phosphorylated by ERK | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| PD98059 | induces partial inhibition of PAP phosphorylation at S537 | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| glutathione affinity Sepharose column chromatography | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + RNA | - |
Mus musculus | diphosphate + RNA(A)n | - |
? | |
| additional information | PAP is a substrate for extracellular signal-regulated kinase | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAP | - |
Mus musculus |
| poly(A) polymerase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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