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Literature summary for 2.7.7.19 extracted from

  • Vethantham, V.; Rao, N.; Manley, J.L.
    Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function (2008), Genes Dev., 22, 499-511.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.19

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells and NIH 3T3 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
small ubiquitin-like modifier in vitro sumoylation inhibits the activity of purified PAP Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
nucleus sumoylation is required to facilitate PAP nuclear localization Mus musculus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 SDS-PAGE Mus musculus
200000
-
 small ubiquitin-like modifier-2/3-modified forms of PAP, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
sumoylation posttranslational sumoylation is required to facilitate PAP nuclear localization and enhances PAP stability Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
bladder
-
 Mus musculus
-
brain
-
 Mus musculus
-
heart
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-
MB-49 cell
-
 Mus musculus
-
MBT-2 cell
-
 Mus musculus
-
spleen
-
 Mus musculus
-
testis
-
 Mus musculus
-
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA
-
 Mus musculus diphosphate + RNA(A)n
-
 ?

Synonyms

Synonyms Comment Organism
PAP
-
 Mus musculus
poly(A) polymerase
-
 Mus musculus