Any feedback?
Literature summary for 2.7.7.15 extracted from
- CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis (2011), Biochim. Biophys. Acta, 1811, 377-385.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| additional information | immunohistochemic analysis of enzyme subcellular localization, overview | Cricetulus griseus | - |
- |
| additional information | immunohistochemic analysis of enzyme subcellular localization, overview | Homo sapiens | - |
- |
| nucleoplasm | - |
Homo sapiens | 5654 | - |
| nucleoplasm | in CHO cells, CCTalpha is nucleoplasmic and colocalized with GFP-progerin in nuclear folds and invaginations | Cricetulus griseus | 5654 | - |
| nucleoplasmic reticulum | - |
Cricetulus griseus | 44195 | - |
| nucleoplasmic reticulum | - |
Homo sapiens | 44195 | - |
| nucleus | lipid activation of the enzyme results in its translocation to the nuclear envelope and expansion of an intranuclear membrane network termed the nucleoplasmic reticulum by a mechanism involving membrane deformation | Cricetulus griseus | 5634 | - |
| nucleus | lipid activation of the enzyme results in its translocation to the nuclear envelope and expansion of an intranuclear membrane network termed the nucleoplasmic reticulum by a mechanism involving membrane deformation | Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + phosphocholine | Cricetulus griseus | - |
diphosphate + CDP-choline | - |
? |  |
| CTP + phosphocholine | Homo sapiens | - |
diphosphate + CDP-choline | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetulus griseus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| CHO cell | - |
Cricetulus griseus | - |
| fibroblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + phosphocholine | - |
Cricetulus griseus | diphosphate + CDP-choline | - |
? | |
| CTP + phosphocholine | - |
Homo sapiens | diphosphate + CDP-choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CCTalpha | - |
Cricetulus griseus |
| CCTalpha | - |
Homo sapiens |
| CTP:phosphocholine cytidylyltransferase alpha | - |
Cricetulus griseus |
| CTP:phosphocholine cytidylyltransferase alpha | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | CTP:phosphocholine cytidylyltransferase alpha is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine synthesis. Lipid activation of the enzyme results in its translocation to the nuclear envelope and expansion of an intranuclear membrane network termed the nucleoplasmic reticulum by a mechanism involving membrane deformation. CCTalpha and lamins specifically cooperate to form the nucleoplasmic reticulum, but the overall structure of the nuclear envelope has a minimal impact on enzyme activity and phosphocholine synthesis | Cricetulus griseus |
| physiological function | CTP:phosphocholine cytidylyltransferase alpha is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine synthesis. The enzyme is not involved in the Hutchinson-Gilford progeria syndrome, overview | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
