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Literature summary for 2.7.7.15 extracted from
- Identification of hydrophobic amino acids required for lipid activation of C. elegans CTP:phosphocholine cytidylyltransferase (2009), Arch. Biochem. Biophys., 492, 10-16.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | lipid activation | Caenorhabditis elegans |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| His-tagged version expressed in Sf9 cell using a baculovirus exression system | Caenorhabditis elegans |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| F260D | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
| F260K | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
| F260L | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
| F260V | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
| F269I | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
| I256S | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
| I257S | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
| L246S | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
| L246S/W249S/I256S/I257S | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
| W249S | part of a putative amphipathic alpha helix | Caenorhabditis elegans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | Q3HKC4 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| TALON Co2+ metal affinity chromatography | Caenorhabditis elegans |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 10 | - |
wild-type protein in the presence of 0.01 mM phosphatidylcholine:oleate | Caenorhabditis elegans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | - |
Caenorhabditis elegans | diphosphate + CDP-choline | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CTP:phosphocholine cytidylyltransferase | - |
Caenorhabditis elegans |
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