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Literature summary for 2.7.7.15 extracted from
- Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice (2007), Biochim. Biophys. Acta, 1771, 845-852.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | probucol does not have any diret stimulatory effect on CCT | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isozyme CCTalpha is expressed in baculovirus-infected cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | loss of the CCTbeta2 isoform expression in mice results in gonadal dysfunction | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P49586 | - |
- |
| Mus musculus | Q811Q9 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | isozyme CCTbeta2 | Mus musculus | - |
| ovary | isozyme CCTbeta2 | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | - |
Mus musculus | diphosphate + CDP-choline | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CCTalpha | isozyme | Mus musculus |
| CCTbeta2 | isozyme | Mus musculus |
| CTP:phosphocholine cytidylyltransferase beta2 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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