Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Lipids | regulation of activity by reversible association with membrane lipids | Mus musculus | |
Lipids | regulation of activity by reversible association with membrane lipids | Homo sapiens | |
Lipids | regulation of activity by reversible association with membrane lipids | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ceramide | short chain ceramides | Homo sapiens | |
ceramide | short chain ceramides | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | membrane associated | Mus musculus | 5737 | - |
cytoplasm | membrane associated | Homo sapiens | 5737 | - |
membrane | enzyme is activated when bound to vesicles | Mus musculus | 16020 | - |
membrane | enzyme is activated when bound to vesicles | Homo sapiens | 16020 | - |
membrane | enzyme is activated when bound to vesicles | Arabidopsis thaliana | 16020 | - |
nucleus | CCTalpha, CCTbeta is not found in the nucleus | Mus musculus | 5634 | - |
nucleus | CCTalpha, CCTbeta is not found in the nucleus | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + choline phosphate | Homo sapiens | rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis | diphosphate + CDP-choline | - |
? | |
CTP + choline phosphate | Mus musculus | rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility | diphosphate + CDP-choline | - |
? | |
CTP + choline phosphate | Arabidopsis thaliana | rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation | diphosphate + CDP-choline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation reduces membrane binding and therefore decreases activity | Mus musculus |
phosphoprotein | phosphorylation reduces membrane binding and therefore decreases activity | Homo sapiens |
phosphoprotein | phosphorylation reduces membrane binding and therefore decreases activity | Arabidopsis thaliana |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
alveolar cell | high expression of enzyme | Mus musculus | - |
alveolar cell | high expression of enzyme | Homo sapiens | - |
brain | equal expression of CCT alpha and CCT beta | Mus musculus | - |
brain | equal expression of CCT alpha and CCT beta | Homo sapiens | - |
additional information | CCTalpha expressed in virtually every tissue | Mus musculus | - |
additional information | CCTalpha expressed in virtually every tissue | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + choline phosphate | - |
Mus musculus | diphosphate + CDP-choline | - |
? | |
CTP + choline phosphate | - |
Homo sapiens | diphosphate + CDP-choline | - |
? | |
CTP + choline phosphate | - |
Arabidopsis thaliana | diphosphate + CDP-choline | - |
? | |
CTP + choline phosphate | rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis | Homo sapiens | diphosphate + CDP-choline | - |
? | |
CTP + choline phosphate | rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility | Mus musculus | diphosphate + CDP-choline | - |
? | |
CTP + choline phosphate | rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation | Arabidopsis thaliana | diphosphate + CDP-choline | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Mus musculus |
dimer | - |
Homo sapiens |
dimer | - |
Arabidopsis thaliana |
Synonyms | Comment | Organism |
---|---|---|
More | different isoforms, CCTalpha and CCTbeta 1, -2, and -3 | Homo sapiens |
More | different isoforms, CCTalpha and CCTbeta 2 and -3, CCTbeta 1 is not found in mice | Mus musculus |
More | two different isoforms | Arabidopsis thaliana |