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Literature summary for 2.7.7.15 extracted from

  • Pelech, S.L.; Jetha, F.; Vance, D.E.
    Trifluoperazine and other anaesthetics inhibit rat liver CTP: phosphocholine cytidylyltransferase (1983), FEBS Lett., 158, 89-92.
    View publication on PubMed
Search for more literature for 2.7.7.15

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine 5fold inhibition of microsomal enzyme at 0.025 mM, 50% inhibition at 0.75mM, addition of saturating amounts of rat liver phospholipid reverses inhibition, no inhibition of hepatocytes at 0.02 mM Rattus norvegicus
Dibucaine 28% inhibition at 0.05 mM Rattus norvegicus
additional information no inhibition by lidocaine or procaine Rattus norvegicus
propanolol 28% inhibition at 0.05 mM Rattus norvegicus
Tetracaine 50% inhibition at 0.05 mM Rattus norvegicus
Trifluoperazine 5fold inhibition of microsomal enzyme at 0.025 mM, 50% inhibition at 0.75mM, addition of saturating amounts of rat liver phospholipid reverses inhibition, no inhibition of hepatocytes at 0.02 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + choline phosphate Rattus norvegicus catalyzes a major rate-limiting step in the biosynthesis of phosphocholine diphosphate + CDPcholine
-
 ?
additional information Rattus norvegicus active form of enzyme on the ER, enzyme in cytosol appears to be latent ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDPcholine
-
 ?
CTP + choline phosphate catalyzes a major rate-limiting step in the biosynthesis of phosphocholine Rattus norvegicus diphosphate + CDPcholine
-
 ?
additional information active form of enzyme on the ER, enzyme in cytosol appears to be latent Rattus norvegicus ?
-
 ?