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Literature summary for 2.7.7.14 extracted from
- Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties (2007), J. Lipid Res., 48, 2172-2181.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-7 cells | Mus musculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.08409 | - |
CTP | isozyme Pcyt2beta, at 37°C | Mus musculus |  |
| 0.102 | - |
CTP | isozyme Pcyt2alpha, at 37°C | Mus musculus | |
| 0.1403 | - |
Ethanolamine phosphate | isozyme Pcyt2beta, at 37°C | Mus musculus | |
| 0.3184 | - |
Ethanolamine phosphate | isozyme Pcyt2alpha, at 37°C | Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 90000 | - |
myc-His-tagged Pcyt2beta, appears as two bands (110000 and 90000 Da), gel filtration | Mus musculus |
| 108000 | - |
myc-His-tagged Pcyt2alpha, gel filtration | Mus musculus |
| 110000 | - |
myc-His-tagged Pcyt2beta, appears as two bands (110000 and 90000 Da), gel filtration | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q922E4 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA Superflow resin chromatography | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Mus musculus | - |
| brain | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| skeletal muscle | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + ethanolamine phosphate | - |
Mus musculus | diphosphate + CDP-ethanolamine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | isozymes Pcyt2alpha and Pcyt2beta proteins can form both homodimeric and heterodimeric complexes | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CTP:phosphoethanolamine cytidylyltransferase | - |
Mus musculus |
| Pcyt2 | - |
Mus musculus |
| Pcyt2alpha | isozyme | Mus musculus |
| Pcyt2beta | isozyme | Mus musculus |
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Release 2023.1 (January 2023)
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