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Literature summary for 2.7.7.14 extracted from
- Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) (2007), Biochem. Cell Biol., 85, 283-300.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| AMP-activated kinase | - |
Homo sapiens | |
| AMP-activated kinase | - |
Rattus norvegicus | |
| AMP-activated kinase | - |
Mus musculus | |
| additional information | does not require the presence of exogenous lipids for optimal activity | Homo sapiens | |
| additional information | does not require the presence of exogenous lipids for optimal activity | Rattus norvegicus | |
| additional information | does not require the presence of exogenous lipids for optimal activity | Mus musculus | |
| paramethoxyamphetamine | stimulates activity | Homo sapiens |  |
| paramethoxyamphetamine | stimulates activity | Rattus norvegicus | |
| paramethoxyamphetamine | stimulates activity | Mus musculus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Saccharomyces cerevisiae |
- |
Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aminoimidazole-4-carboxamide | downregulates Pcyt2 activity | Homo sapiens | |
| aminoimidazole-4-carboxamide | downregulates Pcyt2 activity | Mus musculus | |
| aminoimidazole-4-carboxamide | downregulates Pcyt2 activity | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.053 | - |
Ethanolamine phosphate | - |
Rattus norvegicus | |
| 0.065 | - |
CTP | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Mus musculus | 5829 | - |
| membrane | associated with the membranes of the rough endoplasmic reticulum | Homo sapiens | 16020 | - |
| membrane | associated with the membranes of the rough endoplasmic reticulum | Rattus norvegicus | 16020 | - |
| membrane | associated with the membranes of the rough endoplasmic reticulum | Mus musculus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
SDS-PAGE | Homo sapiens |
| 50000 | - |
SDS-PAGE | Rattus norvegicus |
| 50000 | - |
SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | Q922E4 | - |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Saccharomyces cerevisiae |
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Homo sapiens | - |
| adipocyte | - |
Mus musculus | - |
| adipocyte | high Pcyt2 mRNA content. Negligible amount of Pcyt2beta mRNA, high amount of Pcyt2alpha mRNA | Mus musculus | - |
| brain | low Pcyt2 mRNA content | Mus musculus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Mus musculus | - |
| heart | very low level of Pcyt2alpha | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| kidney | negligible amount of Pcyt2beta mRNA, high amount of Pcyt2alpha mRNA | Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | low Pcyt2 mRNA content. Negligible amount of Pcyt2beta mRNA, high amount of Pcyt2alpha mRNA | Mus musculus | - |
| liver | Pcyt2 stays constant throughout the rat adult stage | Rattus norvegicus | - |
| additional information | Pcyt2 mRNA is barely detected in human kidney | Homo sapiens | - |
| skeletal muscle | low Pcyt2 mRNA content | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + ethanolamine phosphate | - |
Homo sapiens | diphosphate + CDP-ethanolamine | - |
? | |
| CTP + ethanolamine phosphate | - |
Rattus norvegicus | diphosphate + CDP-ethanolamine | - |
? | |
| CTP + ethanolamine phosphate | - |
Saccharomyces cerevisiae | diphosphate + CDP-ethanolamine | - |
? | |
| CTP + ethanolamine phosphate | - |
Mus musculus | diphosphate + CDP-ethanolamine | - |
? | |
| additional information | uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine | Homo sapiens | ? | - |
? | |
| additional information | uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine | Rattus norvegicus | ? | - |
? | |
| additional information | uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
| dimer | - |
Rattus norvegicus |
| dimer | - |
Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CTP:phosphoethanolamine cytidylyltransferase | - |
Homo sapiens |
| CTP:phosphoethanolamine cytidylyltransferase | - |
Rattus norvegicus |
| CTP:phosphoethanolamine cytidylyltransferase | - |
Saccharomyces cerevisiae |
| CTP:phosphoethanolamine cytidylyltransferase | - |
Mus musculus |
| Pcyt2 | - |
Homo sapiens |
| Pcyt2 | - |
Rattus norvegicus |
| Pcyt2 | - |
Saccharomyces cerevisiae |
| Pcyt2 | - |
Mus musculus |
| Pcyt2alpha | longer variant of Pcyt2 | Homo sapiens |
| Pcyt2alpha | longer variant of Pcyt2 | Mus musculus |
| Pcyt2beta | shorter variant of Pcyt2 | Homo sapiens |
| Pcyt2beta | shorter variant of Pcyt2 | Mus musculus |
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Release 2023.1 (January 2023)
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