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Literature summary for 2.7.7.12 extracted from

  • Davit-Spraul, A.; Pourci, M.L.; Ng, K.H.; Soni, T.; Lemonnier, A.
    Regulatory effects of galactose on galactose-1-phosphate uridyltransferase activity on human hepatoblastoma HepG2 cells (1994), FEBS Lett., 354, 232-236.
    View publication on PubMed
Search for more literature for 2.7.7.12

Activating Compound

Activating Compound Comment Organism Structure
D-galactose galactose growth medium induces enzyme activity, not expression, and increases Vmax by about 50% compared to glucose medium Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha-D-galactose 1-phosphate substrate inhibition at concentrations above 1.5 mM Homo sapiens
UDP-glucose substrate inhibition at concentrations above 0.5 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
 alpha-D-galactose 1-phosphate galactose grown cells, pH 8.2 Homo sapiens
0.1
-
 alpha-D-galactose 1-phosphate glucose grown cells, pH 8.2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell hepatoblastoma cell line, grown on glucose or galactose Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.008
-
 HepG2 cells grown on glucose medium Homo sapiens
0.012
-
 HepG2 cells grown on galactose medium Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + alpha-D-galactose 1-phosphate
-
 Homo sapiens alpha-D-glucose 1-phosphate + UDP-galactose
-
 r

Synonyms

Synonyms Comment Organism
GALT
-
 Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens different isozymic pattern in cells grown in glucose, galactose or inosine media
-
 additional information