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Literature summary for 2.7.7.101 extracted from

  • Reichard, P.; Rowen, L.; Eliasson, R.; Hobbs, J.; Eckstein, F.
    Inhibition of primase, the dnaG protein of Escherichia coli by 2-deoxy-2-azidocytidine triphosphate (1978), J. Biol. Chem., 253, 7011-7016 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxy-2'-azidocytidine 5'-triphosphate pronounced inhibition, not reversed by presence of dCTP or CTP. Inhibitor is incorporated into the primer and terminates the extension of the primer strand Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0ABS5
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bacteriophage G4 ssDNA + n rNTP
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Escherichia coli bacteriophage G4 ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate
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