Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.1 extracted from

  • Liang, J.; Wang, P.; Wei, J.; Bao, C.; Han, D.
    Nicotinamide mononucleotide adenylyltransferase 1 protects neural cells against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke through AMP-activated protein kinase activation (2015), Neurochem. Res., 40, 1102-1110.
    View publication on PubMed
Search for more literature for 2.7.7.1

Application

Application Comment Organism
medicine NMNAT1 is a potential therapeutic target for stroke Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information NMNAT1 overexpression reduces brain infarction size and improves behavioral outcomes in mice with ischemic stroke Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + nicotinamide ribonucleotide Mus musculus
-
 diphosphate + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9EPA7 gene Nmnat1
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
 Mus musculus
-
neuron
-
 Mus musculus
-
neuronal cell line
-
 Mus musculus
-
primary cell line
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + nicotinamide ribonucleotide
-
 Mus musculus diphosphate + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
nicotinamide mononucleotide adenylyltransferase 1
-
 Mus musculus
NMNAT1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction NMNAT1 overexpression reduces cell death and apoptosis both in vitro and in vivo. NMNAT1 knockdown exacerbates cell death and apoptosis. NMNAT1 overexpression regulates neuron survival via AMPK activation, as NMNAT1 overexpression enhances AMPKactivity in OGD-treated cortical neurons, and AMPK inhibitor blocks LV-NMNAT1-induced neuroprotection in OGD-treated cortical neurons Mus musculus
physiological function isozyme nicotinamide mononucleotide adenylyltransferase 1 protects neural cells against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke through AMP-activated protein kinase activation. NMNAT1 overexpression reduces brain infarction size and improves behavioral outcomes in mice with ischemic stroke. Role and mechanism of NMNAT1 in the regulation of neural ischemic injuries by using cultured cortical neurons with oxygen-glucose deprivation of ischemic injury in vitro and mouse transient middle cerebral artery occlusion (MCAO) model of stroke in vivo, overview Mus musculus