Cloned (Comment) | Organism |
---|---|
gene Nmnat1, recombinant expression of mouse Nmnat1 non-nuclear-localized gain-of-function mutant gene (m-nonN-Nmnat1) in Caenorhabditis elegans. The transgenic enzyme provides protection from both hypoxia-induced animal death and taxol-induced axonal pathology and significantly lengthens the nematode's lifespan. Loss of function in two genes, haf-1 and dve-1, encoding mitochondrial unfolded protein response (mitoUPR) factors are identified as suppressors. M-nonN-Nmnat1 induces a transcriptional reporter of the mitoUPR gene hsp-6 and provides protection from the mitochondrial proteostasis toxin ethidium bromide. M-nonN-Nmnat1 is also protective against axonal degeneration in Caenorhabditis elegans induced by the chemotherapy drug taxol. Taxol markedly reduces basal expression of a mitoUPR reporter, the expression is restored by m-nonN-Nmnat1 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9EPA7 | gene Nmnat1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
neuron | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
m-nonN-Nmnat1 | - |
Mus musculus |
nicotinamide mononucleotide adenylyltransferase | - |
Mus musculus |
nicotinamide mononucleotide adenylyltransferase type 1 | - |
Mus musculus |
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | UniProt | Mus musculus |
NMNAT1 | - |
Mus musculus |
non-nuclear-localized-Nmnat1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | gain-of-function mutations in the mouse nicotinamide mononucleotide adenylyltransferase type 1, Nmnat1, produce two remarkable phenotypes: protection against traumatic axonal degeneration and reduced hypoxic brain injury, the mechanism involves the mitochondrial unfolded protein response (mitoUPR) factor, penotype, overview | Mus musculus |