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Literature summary for 2.7.7.1 extracted from

  • Zang, S.; Ali, Y.O.; Ruan, K.; Zhai, R.G.
    Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot (2013), EMBO Rep., 14, 87-94.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Source Tissue

Source Tissue Comment Organism Textmining
brain the enzyme localizes in photoreceptor and central brain synapses Drosophila melanogaster
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Synonyms

Synonyms Comment Organism
nicotinamide mononucleotide adenylyltransferase
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Drosophila melanogaster
NMNAT
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Drosophila melanogaster

General Information

General Information Comment Organism
malfunction enzyme loss results in ubiquitination, mislocalization and aggregation of the Bruchpilot protein, and subsequent active zone degeneration Drosophila melanogaster
physiological function the enzyme is required for maintaining active zone structural integrity in Drosophila by interacting with the active zone protein Bruchpilot and shielding it from activity-induced ubiquitin-proteasome-mediated degradation. The enzyme specifically maintains active zone structure by direct protein-protein interaction Drosophila melanogaster