Application | Comment | Organism |
---|---|---|
medicine | the mitochondrial localization of NMNAT activity plays an important role in NMNAT expression-mediated axonal protection | Mus musculus |
Cloned (Comment) | Organism |
---|---|
transgenic mice overexpressing NMNAT1 and the mutant WldS(W258A) are generated | Mus musculus |
transgenic mice overexpressing NMNAT3 are generated | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | naturally occuring mutant mice, wldS, showing delayed Wallerian degeneration phenotype, suggest that axonal degeneration is an active process, the wldS mutation comprises an 85 kb tandem triplicon, which causes overexpression of the chimeric WldS protein composed of the N-terminal 70 aa of Ufd2a/Ube4b, an ubiquitin-chain assembly factor, fused to the complete sequence of NMNAT1 | Mus musculus |
WldS(W258A) | the chimeric WldS protein is composed of the N-terminal 70 aa of Ufd2a/Ube4b, an ubiquitin-chain assembly factor, fused to the complete sequence of NMNAT1, the W258A mutation disrupts the NAD-synthesizing activity | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial matrix | - |
Mus musculus | 5759 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q99JR6 | NMNAT3 | - |
Mus musculus | Q9EPA7 | NMNAT1 | - |
Purification (Comment) | Organism |
---|---|
prepared from cerebrum for activity assays | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + nicotinamide ribonucleotide | - |
Mus musculus | diphosphate + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nicotinamide mononucleotide adenylyltransferase | nicotinate nucleotide can also act as acceptor, see also EC 2.7.7.18 nicotinate-nucleotide adenylyltransferase | Mus musculus |
NMNAT | - |
Mus musculus |
NMNAT1 | nuclear isoform | Mus musculus |
NMNAT3 | mitochondrial isoform | Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
activity assay | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
activity assay | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | NMNAT1 is an enzyme in the NAD biosynthetic pathway that generates NAD in the nucleus | Mus musculus |