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Literature summary for 2.7.7.1 extracted from

  • Sorci, L.; Cimadamore, F.; Scotti, S.; Petrelli, R.; Cappellacci, L.; Franchetti, P.; Orsomando, G.; Magni, G.
    Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis (2007), Biochemistry, 46, 4912-4922.
    View publication on PubMed
Search for more literature for 2.7.7.1

Cloned(Commentary)

Cloned (Comment) Organism
His-tagged isozymes NMNAT1, NMNAT2, and NMNAT3, expression in Escherichia coli strain BL21(DE3) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diphosphate product inhibition, noncompetitive for isozyme NMNAT1, and mixed-type for isozymes NMNAT2 and NMNAT3, both versus ATP and NMN; product inhibition, noncompetitive for isozyme NMNAT1, and mixed-type for isozymes NMNAT2 and NMNAT3, both versus ATP and NMN; product inhibition, noncompetitive for isozyme NMNAT1, and mixed-type for isozymes NMNAT2 and NMNAT3, both versus ATP and NMN Homo sapiens
gallotannin polyphenolic plant metabolite that inhibits all three human NMNATs; polyphenolic plant metabolite that inhibits all three human NMNATs; polyphenolic plant metabolite that inhibits all three human NMNATs Homo sapiens
NaAD+ i.e. nicotinic acid adenine dinucleotide, product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; i.e. nicotinic acid adenine dinucleotide, product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; i.e. nicotinic acid adenine dinucleotide, product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP Homo sapiens
NAD+ product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP Homo sapiens
P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate
-
 Homo sapiens
P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate
-
 Homo sapiens
P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate
-
 Homo sapiens
P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate i.e. Np3AD; i.e. Np3AD; i.e. Np3AD Homo sapiens
P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate i.e. Np4AD; i.e. Np4AD; i.e. Np4AD Homo sapiens
P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate i.e. Nap4AD; i.e. Nap4AD; i.e. Nap4AD Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information initial and steady-state kinetics, kinetic mechanisms of the three NMNAT isozymes, overview Homo sapiens
0.0145
-
 nicotinic acid mononucleotide NMNAT2 Homo sapiens
0.0145
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
0.0213
-
 NMN NMNAT2 Homo sapiens
0.0213
-
 NMN pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
0.0223
-
 NMN NMNAT1 Homo sapiens
0.0223
-
 NMN pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
0.0421
-
 ATP NMNAT3 Homo sapiens
0.0421
-
 ATP pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
0.0585
-
 ATP NMNAT1 Homo sapiens
0.0585
-
 ATP pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
0.0662
-
 NMN NMNAT3 Homo sapiens
0.0662
-
 NMN pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
0.0677
-
 nicotinic acid mononucleotide NMNAT1 Homo sapiens
0.0677
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
0.0889
-
 ATP NMNAT2 Homo sapiens
0.0889
-
 ATP pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
0.111
-
 nicotinic acid mononucleotide NMNAT3 Homo sapiens
0.111
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
0.13
-
 NMNH NMNAT3 Homo sapiens
0.13
-
 NMNH pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
0.276
-
 GTP NMNAT3 Homo sapiens
0.294
-
 NMNH NMNAT1 Homo sapiens
0.294
-
 NMNH pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
0.304
-
 NMNH NMNAT2 Homo sapiens
0.304
-
 NMNH pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
0.35
-
 ITP NMNAT3 Homo sapiens
0.37
-
 tiazofurin monophosphate NMNAT1 Homo sapiens
0.37
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.01
-
 tiazofurin monophosphate NMNAT3 Homo sapiens
2.1
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
100
-
 tiazofurin monophosphate NMNAT2 Homo sapiens
100
-
 tiazofurin riboside 5'-monophosphate above, pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus NMNAT2 Homo sapiens 5794
-
Golgi apparatus isozyme NMNAT2 Homo sapiens 5794
-
mitochondrion NMNAT3 Homo sapiens 5739
-
mitochondrion isozyme NMNAT3 Homo sapiens 5739
-
nucleus Nmnat1 Homo sapiens 5634
-
nucleus isozyme NMNAT1 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ most effective ion with NMNAT2 and NMNAT3 Homo sapiens
Mg2+ most effective ion with isozymes NMNAT2 and NMNAT3 Homo sapiens
additional information NMNAT activity requires the presence of divalent cations. Homo sapiens
Zn2+ most effective ion with NMNAT1 Homo sapiens
Zn2+ most effective ion with isozyme NMNAT1 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32700
-
 for NMNAT3, SDS-PAGE Homo sapiens
32700
-
 x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE Homo sapiens
36000
-
 for NMNAT1, SDS-PAGE Homo sapiens
36000
-
 x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE Homo sapiens
37000
-
 for NMNAT2, SDS-PAGE Homo sapiens
37000
-
 x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NMN Homo sapiens
-
 diphosphate + NAD+
-
 ?
GTP + nicotinamide ribonucleotide Homo sapiens only isoenzyme NMNAT3 nicotineamide guanine dinucleotide + diphosphate
-
 ?
ITP + nicotinamide ribonucleotide Homo sapiens only isoenzyme NMNAT3 nicotinamide hypoxanthine dinucleotide + diphosphate
-
 ?
NMN + ATP Homo sapiens
-
 NAD+ + diphosphate
-
 ?
tiazofurin monophosphate + ATP Homo sapiens
-
 tiazofurin adenine dinucleotide + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96T66
-
-
Homo sapiens Q96T66 isozyme NMNAT3; isozyme NMNAT3
-
Homo sapiens Q9BZQ4
-
-
Homo sapiens Q9BZQ4 isozyme NMNAT2; isozyme NMNAT2
-
Homo sapiens Q9HAN9
-
-
Homo sapiens Q9HAN9 isozyme NMNAT1; isozyme NMNAT1
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged isozymes NMNAT1, NMNAT2, and NMNAT3 from Escherichia coli strain BL21(DE3) by nickel or TALON affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain predominance of isozyme NMNAT1 Homo sapiens
-
Hep-G2 cell hepatocellular carcinoma cell line, predominance of isozyme NMNAT1, isozyme NMNAT3 is only present in liver and HepG2 cells Homo sapiens
-
liver
-
 Homo sapiens
-
liver predominance of isozyme NMNAT1, isozyme NMNAT3 is only present in liver and HepG2 cells Homo sapiens
-
SK-HEP-1 cell hepatocellular carcinoma cell line, isozyme NMNAT2 is found exclusively in SK-HEP1 cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + nicotinate D-ribonucleotide
-
 Homo sapiens diphosphate + nicotinate adenine dinucleotide i.e. nicotinic acid adenine dinucleotide ?
ATP + NMN
-
 Homo sapiens diphosphate + NAD+
-
 ?
ATP + NMN ATP binds before NMN with nuclear isozyme NMNAT1 and Golgi apparatus NMNAT2, but the opposite order is observed with the mitochondrial isozyme NMNAT3 Homo sapiens diphosphate + NAD+
-
 ?
ATP + NMNH
-
 Homo sapiens diphosphate + NADH
-
 ?
ATP + tiazofurin 5'-monophosphate i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2 Homo sapiens ?
-
 ?
ATP + tiazofurin monophosphate i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2 Homo sapiens ?
-
 ?
GTP + nicotinamide ribonucleotide only isoenzyme NMNAT3 Homo sapiens nicotineamide guanine dinucleotide + diphosphate
-
 ?
GTP + NMN substrates of isozyme NMNAT3 Homo sapiens diphosphate + NGD+ i.e. nicotinamide guanosine dinucleotide ?
ITP + nicotinamide ribonucleotide only isoenzyme NMNAT3 Homo sapiens nicotinamide hypoxanthine dinucleotide + diphosphate
-
 ?
ITP + NMN substrates of isozyme NMNAT3 Homo sapiens diphosphate + inosine nicotinamide dinucleotide i.e. nicotinamide hypoxanthine dinucleotide ?
nicotinic acid mononucleotide + ATP
-
 Homo sapiens nicotinic acid adenine dinucleotide + diphosphate
-
 ?
NMN + ATP
-
 Homo sapiens NAD+ + diphosphate
-
 ?
tiazofurin monophosphate + ATP
-
 Homo sapiens tiazofurin adenine dinucleotide + diphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE Homo sapiens
hexamer NMNAT1 Homo sapiens
monomer NMNAT2 Homo sapiens
tetramer NMNAT3 Homo sapiens

Synonyms

Synonyms Comment Organism
human nicotinamide mononucleotide adenylyl-transferase
-
 Homo sapiens
nicotinamide mononucleotide adenylyl-transferase
-
 Homo sapiens
NMN-adenylyltransferase
-
 Homo sapiens
NMNAT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.42
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
0.55
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.5
-
 ATP pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.5
-
 NMN pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
3.3
-
 NMNH pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
3.8
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
6.9
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
7.2
-
 NMNH pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
8.8
-
 ATP pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
8.8
-
 NMN pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
14.9
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
18.6
-
 NMNH pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
42.9
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
53.8
-
 NMN pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
53.9
-
 ATP pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0217
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT3 Homo sapiens
0.0217
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate NaMN Homo sapiens
0.023
-
 NaAD+ product inhibition of NMNAT2, substrate ATP Homo sapiens
0.0242
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT2 Homo sapiens
0.0242
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP Homo sapiens
0.0258
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT2 Homo sapiens
0.0258
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN Homo sapiens
0.0298
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT3 Homo sapiens
0.0298
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP Homo sapiens
0.0311
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT1 Homo sapiens
0.0311
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN Homo sapiens
0.0315
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT2 Homo sapiens
0.0315
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN Homo sapiens
0.0328
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT3 Homo sapiens
0.0328
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP Homo sapiens
0.0359
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT2 Homo sapiens
0.0359
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP Homo sapiens
0.0369
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT1 Homo sapiens
0.0369
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate NaMN Homo sapiens
0.0406
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT3 Homo sapiens
0.0406
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP Homo sapiens
0.041
-
 NaAD+ product inhibition of NMNAT2, substrate NMN Homo sapiens
0.0431
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT3 Homo sapiens
0.0431
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP Homo sapiens
0.0492
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT1 Homo sapiens
0.0492
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP Homo sapiens
0.0563
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT1 Homo sapiens
0.0563
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP Homo sapiens
0.0591
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT1 Homo sapiens
0.0591
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP Homo sapiens
0.0668
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT3 Homo sapiens
0.0668
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN Homo sapiens
0.067
-
 NAD+ product inhibition of NMNAT2, substrate NMN Homo sapiens
0.0679
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT1 Homo sapiens
0.0679
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN Homo sapiens
0.0736
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT3 Homo sapiens
0.0736
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN Homo sapiens
0.0845
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT1 Homo sapiens
0.0845
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP Homo sapiens
0.0883
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT3 Homo sapiens
0.0883
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN Homo sapiens
0.089
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT1 Homo sapiens
0.089
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN Homo sapiens
0.095
-
 NAD+ product inhibition of NMNAT2, substrate ATP Homo sapiens
0.1257
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT2 Homo sapiens
0.1257
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate NaMN Homo sapiens
0.16
-
 diphosphate product inhibition of NMNAT2, substrate NMN Homo sapiens
0.1745
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT2 Homo sapiens
0.1745
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP Homo sapiens
0.175
-
 diphosphate product inhibition of NMNAT1, substrate ATP Homo sapiens
0.205
-
 NaAD+ product inhibition of NMNAT3, substrate ATP Homo sapiens
0.305
-
 NaAD+ product inhibition of NMNAT1, substrate ATP Homo sapiens
0.3283
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT2 Homo sapiens
0.3283
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN Homo sapiens
0.334
-
 diphosphate product inhibition of NMNAT3, substrate ATP Homo sapiens
0.361
-
 diphosphate product inhibition of NMNAT2, substrate ATP Homo sapiens
0.364
-
 NaAD+ product inhibition of NMNAT3, substrate NMN Homo sapiens
0.39
-
 diphosphate product inhibition of NMNAT1, substrate NMN Homo sapiens
0.418
-
 NAD+ product inhibition of NMNAT1, substrate NMN Homo sapiens
0.502
-
 NaAD+ product inhibition of NMNAT1, substrate NMN Homo sapiens
0.6576
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT2 Homo sapiens
0.6576
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP Homo sapiens
0.749
-
 NAD+ product inhibition of NMNAT1, substrate ATP Homo sapiens
1
-
 diphosphate product inhibition of NMNAT3, substrate NMN Homo sapiens
1.017
-
 NAD+ product inhibition of NMNAT3, substrate NMN Homo sapiens
1.418
-
 NAD+ product inhibition of NMNAT3, substrate ATP Homo sapiens