Literature summary for 2.7.7.1 extracted from

Garavaglia, S.; D'Angelo, I.; Emanuelli, M.; Carnevali, F.; Pierella, F.; Magni, G.; Rizzi, M.
Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis (2002), J. Biol. Chem., 277, 8524-8530.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, 20 mg/ml protein mixed with an equal volume of reservoir solution containing 1.8 M ammonium sulfate, 0.1 M Tris, pH 8 and 4% v/v isopropyl alcohol, 4-5 days at 20°C, monoclinic space group P21 if 20% glycerol is used, hexagonal space group P6322 if light paraffin oil is used	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + nicotinamide ribonucleotide	Homo sapiens	-	diphosphate + NAD+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HAN9	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + nicotinamide ribonucleotide	-	Homo sapiens	diphosphate + NAD+	-	?
ATP + nicotinamide ribonucleotide	i.e. NMN or nicotinamide mononucleotide	Homo sapiens	diphosphate + NAD+	-	r
ATP + nicotinate ribonucleotide	i.e. nicotinate mononucleotide	Homo sapiens	diphosphate + nicotinic acid-adenine dinucleotide	-	r

Subunits

Subunits	Comment	Organism
hexamer	alpha/beta-topology subunits, X-ray crystallography, barrel-like hexamer	Homo sapiens

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Release 2023.1 (January 2023)