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Literature summary for 2.7.6.5 extracted from

  • Jones, G.H.
    Activation of ATP:GTP 3-pyrophosphotransferase (guanosine pentaphosphate synthetase) in Streptomyces antibioticus (1994), J. Bacteriol., 176, 1482-1487.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
methanol maximal stimulation of GPSI by 20% v/v Streptomyces antibioticus
additional information no activation by ribosomes Streptomyces antibioticus
additional information GPS I can be activated by incubation with crude mycelial extract, activation is partially inhibited by the inclusion of trypsin inhibitor in reaction mixture Streptomyces antibioticus
mRNA synthetic, e.g. poly(U), stimulates, level of stimulation is greater in presence of RNA and poly(U) together than with either RNA alone, no activation by ribosomes Streptomyces antibioticus
tRNA uncharged or charged, stimulation, level of stimulation is greater in presence of RNA and poly(U) together than with either RNA alone Streptomyces antibioticus
Trypsin incubation with low levels of trypsin activates Streptomyces antibioticus

Organism

Organism UniProt Comment Textmining
Streptomyces antibioticus
-
2 enzyme forms: GPS I
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Streptomyces antibioticus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP
-
Streptomyces antibioticus AMP + guanosine 3'-diphosphate 5'-triphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Streptomyces antibioticus