Literature summary for 2.7.6.1 extracted from

Jimenez, A.; Santos, M.A.; Revuelta, J.L.
Phosphoribosyl pyrophosphate synthetase activity affects growth and riboflavin production in Ashbya gossypii (2008), BMC Biotechnol., 8, 67.

Search for more literature for 2.7.6.1

Application

Application	Comment	Organism
synthesis	the enzyme is useful in industrial production of the vitamin riboflavin using the fungus Ashbya gossypii	Eremothecium gossypii

Cloned(Commentary)

Cloned (Comment)	Organism
genes AGR371C and AGL080C, overexpression of wild-type and mutant deregulated isozymes Agr371cp and Agl080cp, phylogenetic tree of the PRS proteins from Ashbya gossypii and Saccharomyces cerevisiae	Eremothecium gossypii

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of engineered AGR371C and AGL080C mutant strains, which show increased riboflavin synthesis compared to the wild-type strain	Eremothecium gossypii

Organism

Organism	UniProt	Comment	Textmining
Eremothecium gossypii	-	strain ATCC 10895, two genes AGR371C and AGL080C encode isozymes AgPRS2,4 and AgPRS3, respectively	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.01	-	wild-type strain	Eremothecium gossypii
0.011	0.012	mutant strain GPD-PRS2,4, engineered gene AGR371C	Eremothecium gossypii
0.017	0.018	mutant strain GPD-PRS3, engineered gene AGL080C	Eremothecium gossypii

Synonyms

Synonyms	Comment	Organism
PRPP synthetase	-	Eremothecium gossypii
PRS	-	Eremothecium gossypii

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Release 2023.1 (January 2023)