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Literature summary for 2.7.6.1 extracted from

  • Schubert, K.R.; Switzer, R.L.; Shelton, E.
    Studies of the quaternary structure and the chemical properties of phosphoribosylpyrophosphate synthetase from Salmonella typhimurium (1975), J. Biol. Chem., 250, 7492-7500.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
enzyme occurs in multiple states of aggregation Salmonella enterica subsp. enterica serovar Typhimurium
30400
-
x * 30400, sedimentation equilibrium analysis of enzyme dissociated in 6 M guanidine hydrochloride Salmonella enterica subsp. enterica serovar Typhimurium
33800
-
x * 33800, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
160000
-
ultracentrifugation Salmonella enterica subsp. enterica serovar Typhimurium
200000 340000 sucrose density gradient sedimentation Salmonella enterica subsp. enterica serovar Typhimurium
310000
-
gel filtration Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-ribose 5-phosphate Salmonella enterica subsp. enterica serovar Typhimurium the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r
ATP + D-ribose 5-phosphate Salmonella enterica subsp. enterica serovar Typhimurium Su 422 the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
Su 422 strain
-
Salmonella enterica subsp. enterica serovar Typhimurium Su 422
-
Su 422 strain
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate fractionation Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-ribose 5-phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r
ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r
ATP + D-ribose 5-phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium Su 422 AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r
ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Salmonella enterica subsp. enterica serovar Typhimurium Su 422 AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r

Subunits

Subunits Comment Organism
? x * 30400, sedimentation equilibrium analysis of enzyme dissociated in 6 M guanidine hydrochloride Salmonella enterica subsp. enterica serovar Typhimurium
? x * 33800, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium