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Literature summary for 2.7.4.8 extracted from

  • Miller, W.H.; Beauchamp, L.M.; Meade, E.; Reardon, J.E.; Biron, K.K.; Smith, A.A.; Goss, C.A.; Miller, R.L.
    Phosphorylation of ganciclovir phosphonate by cellular GMP kinase determines the stereoselectivity of anti-human cytomegalovirus activity (2000), Nucleosides Nucleotides Nucleic Acids, 19, 341-356.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.026
-
 GMP pH 7.5, 37ºC Homo sapiens
0.03
-
 dGMP pH 7.5, 37ºC Homo sapiens
0.047
-
 ganciclovir monophosphate pH 7.5, 37ºC Homo sapiens
0.052
-
 (R)-ganciclovir phosphonate pH 7.5, 37ºC Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sus scrofa
-
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid i.e. R-ganciclovir phosphonate, (S) enantiomer 100fold less efficient, used for racemic resolution Homo sapiens (R)-ganciclovir phosphonate monophosphate
-
 ?
ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid i.e. R-ganciclovir phosphonate, (S) enantiomer 100fold less efficient, used for racemic resolution Sus scrofa (R)-ganciclovir phosphonate monophosphate
-
 ?
ATP + (R)-ganciclovir phosphonate
-
 Homo sapiens ?
-
 ?
ATP + ganciclovir monophosphate
-
 Homo sapiens ?
-
 ?