Cloned (Comment) | Organism |
---|---|
gene ndk, recombinant expression of wild-type and mutant enzymes, quantitative real-time PCR expression analysis | Pseudomonas aeruginosa |
Protein Variants | Comment | Organism |
---|---|---|
H117Q | site-directed mutagenesis, inactive mutant | Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | Q59636 | and mutant strains, overview, gene ndk | - |
Synonyms | Comment | Organism |
---|---|---|
NDK | - |
Pseudomonas aeruginosa |
nucleoside diphosphate kinase | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
metabolism | nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-kappaB signaling pathways | Pseudomonas aeruginosa |
physiological function | nucleoside diphosphate kinase mediates bacterially induced toxicity against eukaryotic cells. Bacterial Ndk, with the aid of an additional bacterial factor, flagellin, induces expression of the proinflammatory cytokines interleukin-1alpha and -1beta in human host cells A-549. Cytokine induction appears to be dependent on the kinase activity of Ndk and is mediated via the NF-kappaB signaling pathway. Flagellin is required for the induction of the IL-1alpha and IL-1beta genes. Ndk activates the Akt signaling pathway, which acts upstream of NF-kappaB, as well as caspase-1, which is a key component of inflammasome | Pseudomonas aeruginosa |