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Literature summary for 2.7.4.6 extracted from

  • Kim, Y.J.; Lee, J.H.; Lee, Y.; Jia, J.; Paek, S.H.; Kim, H.B.; Jin, S.; Ha, U.H.
    Nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-kappaB signaling pathways (2014), Infect. Immun., 82, 3252-3260.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene ndk, recombinant expression of wild-type and mutant enzymes, quantitative real-time PCR expression analysis Pseudomonas aeruginosa

Protein Variants

Protein Variants Comment Organism
H117Q site-directed mutagenesis, inactive mutant Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q59636 and mutant strains, overview, gene ndk
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Synonyms

Synonyms Comment Organism
NDK
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Pseudomonas aeruginosa
nucleoside diphosphate kinase
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Pseudomonas aeruginosa

General Information

General Information Comment Organism
metabolism nucleoside diphosphate kinase and flagellin from Pseudomonas aeruginosa induce interleukin 1 expression via the Akt/NF-kappaB signaling pathways Pseudomonas aeruginosa
physiological function nucleoside diphosphate kinase mediates bacterially induced toxicity against eukaryotic cells. Bacterial Ndk, with the aid of an additional bacterial factor, flagellin, induces expression of the proinflammatory cytokines interleukin-1alpha and -1beta in human host cells A-549. Cytokine induction appears to be dependent on the kinase activity of Ndk and is mediated via the NF-kappaB signaling pathway. Flagellin is required for the induction of the IL-1alpha and IL-1beta genes. Ndk activates the Akt signaling pathway, which acts upstream of NF-kappaB, as well as caspase-1, which is a key component of inflammasome Pseudomonas aeruginosa