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Literature summary for 2.7.4.6 extracted from

  • Sun, J.; Wang, X.; Lau, A.; Liao, T.Y.; Bucci, C.; Hmama, Z.
    Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages (2010), PLoS ONE, 5, e8769.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NDP Mycobacterium tuberculosis
-
 ADP + NTP
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GDP
-
 Mycobacterium tuberculosis ADP + GTP
-
 ?
ATP + NDP
-
 Mycobacterium tuberculosis ADP + NTP
-
 ?

Subunits

Subunits Comment Organism
? x * about 15000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
NDK
-
 Mycobacterium tuberculosis
nucleoside diphosphate kinase
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function nucleoside diphosphate kinase exhibits GTPase activating protein activity towards Rab5 and Rab7. The enzyme is a putative virulence factor that inhibits phagosome maturation and promotes survival of mycobacteria within the macrophage Mycobacterium tuberculosis