Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p-chloromercuribenzoate | pI 7.3-isoform, DTT restores, but not in the presence of urea, ATP or dTDP protects | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Km-values of different pI-enzyme variants of ATP or GTP and TDP or CDP as substrates | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | requirement, about half as effective as Mg2+, Mn2+ or Co2+, pI 7.3-enzyme variant | Homo sapiens | |
Co2+ | requirement | Homo sapiens | |
Co2+ | equally effective as Mg2+ or Mn2+, pI 7.3-enzyme variant | Homo sapiens | |
Mg2+ | equally effective as Mn2+ or Co2+, pI 7.3-enzyme variant | Homo sapiens | |
Mn2+ | requirement | Homo sapiens | |
Mn2+ | equally effective as Co2+, pI 7.3-enzyme variant | Homo sapiens | |
Mn2+ | equally effective as Mg2+ | Homo sapiens | |
additional information | no activation by Cu2+ or monovalent cations | Homo sapiens | |
Zn2+ | not | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | 100000 | erythrocytic enzyme variants | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NDP + NTP | Homo sapiens | - |
NTP + NDP | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
marked isoelectric variability with pIs from 5.4 to 8.3 | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate | the catalytic mechanism involves a phosphoenzyme intermediate | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + CDP | - |
Homo sapiens | ADP + CTP | - |
? | |
ATP + dTDP | - |
Homo sapiens | ADP + dTTP | - |
? | |
GTP + CDP | - |
Homo sapiens | GDP + CTP | - |
? | |
GTP + dTDP | - |
Homo sapiens | GDP + dTTP | - |
? | |
NDP + NTP | - |
Homo sapiens | NTP + NDP | - |
r | |
NTP + nucleoside diphosphate | substrate: 5-fluoro-UTP | Homo sapiens | NDP + NTP | - |
r | |
NTP + nucleoside diphosphate | substrate 8-aza-UDP, human erythrocytic pI-variant 5.8 | Homo sapiens | NDP + NTP | - |
r |