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Literature summary for 2.7.4.3 extracted from
- Adenylate kinase isozyme 2 is essential for growth and development of Drosophila melanogaster (2009), Comp. Biochem. Physiol. B, 153, 29-38.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Drosophila melanogaster |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibited by N-ethylmaleimide | Drosophila melanogaster |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | localized in the mitochondrial intermembrane space | Drosophila melanogaster | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 27000 | - |
SDS-PAGE | Drosophila melanogaster |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | Q9U915 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | - |
Drosophila melanogaster | - |
| embryo | - |
Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + AMP | - |
Drosophila melanogaster | ADP + ADP | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| adenylate kinase isozyme 2 | - |
Drosophila melanogaster |
| AK2 | isozyme | Drosophila melanogaster |
| ATP:AMP phosphotransferase | - |
Drosophila melanogaster |
| DAK2 | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | although homozygous adenylate kinsase 2 mutated embryos develop without any visible defects, their growth ceases and they die before reaching the third instar larval stage | Drosophila melanogaster |
| physiological function | maternally provided adenylate kianse 2 is sufficient for embryonic development, adenylate kinase 2 plays a critical role in adenine nucleotide metabolism in the mitochondrial intermembrane space and is essential for growth in Drosophila melanogaster | Drosophila melanogaster |
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