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Literature summary for 2.7.4.25 extracted from
- Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv (2008), J. Mol. Model., 14, 427-434.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Mycobacterium tuberculosis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mycobacterium tuberculosis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + CMP | Mycobacterium tuberculosis | - |
ADP + CDP | - |
? | |
| ATP + CMP | Mycobacterium tuberculosis H37Rv | - |
ADP + CDP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
strain H37Rv | - |
| Mycobacterium tuberculosis | P9WPA9 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WPA9 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + CMP | - |
Mycobacterium tuberculosis | ADP + CDP | - |
? | |
| ATP + CMP | - |
Mycobacterium tuberculosis H37Rv | ADP + CDP | - |
? | |
| ATP + dCMP | - |
Mycobacterium tuberculosis | ADP + dCDP | - |
? | |
| additional information | modelling of CMPK in apo form and in complex with cytidine 5'-monophosphate, structure analysis, overview | Mycobacterium tuberculosis | ? | - |
? | |
| additional information | modelling of CMPK in apo form and in complex with cytidine 5'-monophosphate, structure analysis, overview | Mycobacterium tuberculosis H37Rv | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | enzyme structure modelling with or without bound substrate, molecular dynamics simulations, comparative analysis, overview | Mycobacterium tuberculosis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bacterial cytidylate kinase | - |
Mycobacterium tuberculosis |
| CMP kinase | - |
Mycobacterium tuberculosis |
| CMPK | - |
Mycobacterium tuberculosis |
| cytidine monophosphate kinase | - |
Mycobacterium tuberculosis |
| cytidylate kinase | - |
Mycobacterium tuberculosis |
| More | CMP kinases belong to the nucleoside monophosphate kinase, NMK, family, key enzymes in the metabolism of nucleotides | Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mycobacterium tuberculosis | |
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