Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.4.2 extracted from

  • Schulte, A.E.; Van der Heijden, R.; Verpoorte, R.
    Purification and characterization of phosphomevalonate kinase from Catharanthus roseus (1999), Phytochemistry, 52, 975-983.
No PubMed abstract available

General Stability

General Stability Organism
sulfhydryl reagents are not essential to protect the activity of phosphomevalonate kinase Catharanthus roseus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.22
-
ATP pH 7.5, 30°C Catharanthus roseus
0.35
-
phosphomevalonate pH 7.5, 30°C Catharanthus roseus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ divalent cation required for activity, Mg2+ most effective Catharanthus roseus
Mn2+ 52% of activity with Mg2+ Catharanthus roseus
Ni2+ 4.7% of activity with Mg2+ Catharanthus roseus
Zn2+ 22% of activity with Mg2+ Catharanthus roseus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
128000
-
gel filtration Catharanthus roseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (R)-5-phosphomevalonate Catharanthus roseus involved in isoprenoid biosynthesis pathway ADP + 5-diphosphomevalonate
-
?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Q Sepharose, Phenyl Sepharose, Sephacryl S200, Mono Q, gel filtration, Shodex KW803 Catharanthus roseus

Source Tissue

Source Tissue Comment Organism Textmining
cell suspension culture
-
Catharanthus roseus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.21
-
-
Catharanthus roseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-5-phosphomevalonate involved in isoprenoid biosynthesis pathway Catharanthus roseus ADP + 5-diphosphomevalonate
-
?
ATP + 5-phosphomevalonate
-
Catharanthus roseus ADP + 5-diphosphomevalonate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 9 sharp drop in activity below pH 7.0 and above pH 9.0 Catharanthus roseus