BRENDA - Enzyme Database
show all sequences of 2.7.4.14

The contribution of CMP kinase to the efficiency of DNA repair

Tsao, N.; Lee, M.H.; Zhang, W.; Cheng, Y.C.; Chang, Z.F.; Cell Cycle 14, 354-363 (2015)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
additional information
enzyme knockdown in MCF-7 cells using a CMPK shRNA lentivirus
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
localization of enzyme CMPK at DNA damage sites, co-localization and complex formation with Tip60 and ribonucleotide reductase
Homo sapiens
5634
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + CMP
Homo sapiens
-
ADP + CDP
-
-
?
ATP + UMP
Homo sapiens
-
ADP + UDP
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P30085
gene CMPK1
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
breast adenocarcinoma cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + CMP
-
737991
Homo sapiens
ADP + CDP
-
-
-
?
ATP + CMP
preferred substrate
737991
Homo sapiens
ADP + CDP
-
-
-
?
ATP + dCMP
-
737991
Homo sapiens
ADP + dCDP
-
-
-
?
ATP + dUMP
-
737991
Homo sapiens
ADP + dUDP
-
-
-
?
ATP + UMP
-
737991
Homo sapiens
ADP + UDP
-
-
-
?
ATP + UMP
preferred substrate
737991
Homo sapiens
ADP + UDP
-
-
-
?
additional information
CMP and UMP are the preferred substrates for purified CMPK, and it has lower affinity to dCMP and dUMP
737991
Homo sapiens
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
enzyme knockdown in MCF-7 cells using a CMPK shRNA lentivirus
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
localization of enzyme CMPK at DNA damage sites, co-localization and complex formation with Tip60 and ribonucleotide reductase
Homo sapiens
5634
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
required
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + CMP
Homo sapiens
-
ADP + CDP
-
-
?
ATP + UMP
Homo sapiens
-
ADP + UDP
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
breast adenocarcinoma cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + CMP
-
737991
Homo sapiens
ADP + CDP
-
-
-
?
ATP + CMP
preferred substrate
737991
Homo sapiens
ADP + CDP
-
-
-
?
ATP + dCMP
-
737991
Homo sapiens
ADP + dCDP
-
-
-
?
ATP + dUMP
-
737991
Homo sapiens
ADP + dUDP
-
-
-
?
ATP + UMP
-
737991
Homo sapiens
ADP + UDP
-
-
-
?
ATP + UMP
preferred substrate
737991
Homo sapiens
ADP + UDP
-
-
-
?
additional information
CMP and UMP are the preferred substrates for purified CMPK, and it has lower affinity to dCMP and dUMP
737991
Homo sapiens
?
-
-
-
-
General Information
General Information
Commentary
Organism
malfunction
knockdown of CMPK delays DNA repair during recovery from UV damage in serum-deprived cells but not in the cells without serum deprivation. Exogenous supply of cytidine or deoxycytidine facilitates DNA repair dependent on CMPK in serum-deprived cells. But CMPK knockdown does not affect the steady state level of dCTP in serum-deprived cells. Re-expression of wild-type but not N-terminus deleted CMPK restores the efficiency of DNA repair in CMPK knockdown cells
Homo sapiens
additional information
the N-terminal region of CMPK is essential for the complex formation and recruitment to DNA damage sites
Homo sapiens
physiological function
the enzyme enzyme catalyzes CDP formation in DNA repair, the synthesis of dCDP or CDP determines the rate of repair. The N-terminal 32-amino-acid of enzyme CMPK is required for its recruitment to DNA damage sites in a Tip60-dependent manner, complex of CMPK/RNR/Tip60 and the recruitment to the sites of DNA damage, overview. Site-specific dCDP formation via CMPK provides a means to facilitate DNA repair in serum-deprived cells, analysis of functional contribution of CMPK to dCTP pool and the rate of DNA compared in MCF-7 cells in serum-containing and serum-deprived conditions
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
knockdown of CMPK delays DNA repair during recovery from UV damage in serum-deprived cells but not in the cells without serum deprivation. Exogenous supply of cytidine or deoxycytidine facilitates DNA repair dependent on CMPK in serum-deprived cells. But CMPK knockdown does not affect the steady state level of dCTP in serum-deprived cells. Re-expression of wild-type but not N-terminus deleted CMPK restores the efficiency of DNA repair in CMPK knockdown cells
Homo sapiens
additional information
the N-terminal region of CMPK is essential for the complex formation and recruitment to DNA damage sites
Homo sapiens
physiological function
the enzyme enzyme catalyzes CDP formation in DNA repair, the synthesis of dCDP or CDP determines the rate of repair. The N-terminal 32-amino-acid of enzyme CMPK is required for its recruitment to DNA damage sites in a Tip60-dependent manner, complex of CMPK/RNR/Tip60 and the recruitment to the sites of DNA damage, overview. Site-specific dCDP formation via CMPK provides a means to facilitate DNA repair in serum-deprived cells, analysis of functional contribution of CMPK to dCTP pool and the rate of DNA compared in MCF-7 cells in serum-containing and serum-deprived conditions
Homo sapiens
Other publictions for EC 2.7.4.14
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
739215
Topalis
Resistance to the nucleotide a ...
Homo sapiens
Oncotarget
7
10386-10401
2016
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1
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3
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11
1
1
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9
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3
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3
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18
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1
11
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1
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1
1
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11
1
1
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9
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3
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18
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1
11
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4
4
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11
11
739700
Liu
Prognostic significance of nuc ...
Homo sapiens
Sci. Rep.
6
32027
2016
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1
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2
2
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737991
Tsao
The contribution of CMP kinase ...
Homo sapiens
Cell Cycle
14
354-363
2015
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1
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1
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7
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3
3
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702166
Liou
Modulation of human UMP/CMP ki ...
Homo sapiens
Biochem. Pharmacol.
79
381-388
2010
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7
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7
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692040
Kocabas
Gemcitabine pharmacogenomics: ...
Homo sapiens
Drug Metab. Dispos.
36
1951-1959
2008
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1
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1
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Xu
Human UMP-CMP kinase 2, a nove ...
Homo sapiens
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1563-1571
2008
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Lorenz
The influence of proline isome ...
Dictyostelium discoideum
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673598
Topalis
Nucleotide binding to human UM ...
Homo sapiens
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1
1
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6
5
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676227
Alexandre
Enantioselectivity of human AM ...
Homo sapiens
Nucleic Acids Res.
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4895-4904
2007
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1
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12
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12
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12
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12
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694478
Topalis
Looking for new pyrimidine acy ...
Homo sapiens
Nucleosides Nucleotides Nucleic Acids
26
1369-1373
2007
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1
1
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4
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694479
Alexandre
Enantio-selectivity of human n ...
Homo sapiens
Nucleosides Nucleotides Nucleic Acids
26
1375-1379
2007
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11
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1
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4
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1
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12
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1
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Hewitt
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Arabidopsis thaliana
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91-99
2005
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645155
Curbo
The Drosophila melanogaster UM ...
Drosophila melanogaster
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311
440-445
2003
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1
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2
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645162
Pasti
Reaction of human UMP-CMP kina ...
Dictyostelium sp., Homo sapiens
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1
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16
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14
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16
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14
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645161
Liou
Characterization of human UMP/ ...
Homo sapiens
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1
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4
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27
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27
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645160
Pearman
Characterization of human UMP- ...
Homo sapiens
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21
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1
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645152
Hutter
Phosphoryl transfer by a conce ...
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9
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2000
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645156
Van Rompay
Phosphorylation of deoxycytidi ...
Homo sapiens
Mol. Pharmacol.
56
562-569
1999
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1
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5
2
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3
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9
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1
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2
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9
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645153
Zhou
Cloning, expression in Escheri ...
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Plant Physiol.
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1998
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1
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4
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1
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1
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1
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1
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1
2
1
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645157
Okajima
Exchange of nucleoside monopho ...
Sus scrofa
J. Biochem.
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359-367
1998
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1
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Seagrave
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Enzymes of pyrimidine deoxyrib ...
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Scott
Kinetics and equilibria of pyr ...
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Orengo
Pyrimidine nucleoside monophos ...
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Anderson
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Maness
Activation of rat liver pyrimi ...
Rattus norvegicus
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Teng
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Maness
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Gravey
ATP:UMP-CMP phosphotransferase ...
Tetrahymena pyriformis
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Ruffner
Adenosine triphosphate: uridin ...
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Hurwitz
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