Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | activates | Rattus norvegicus | |
dithiothreitol | activates | Rattus norvegicus | |
glutathione | activates | Rattus norvegicus | |
L-Cys | activates | Rattus norvegicus | |
reduced DL-alpha-lipoic acid | activates | Rattus norvegicus | |
thioredoxin | activity is strictly dependent upon sulfhydryl reducing agents. Reduced thioredoxin is by far the most effective | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CMP | above 0.13 mM, substrate inhibition | Rattus norvegicus | |
additional information | no substrate inhibition with 3 mM dCMP and 1 mM UMP | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.027 | - |
dCMP | - |
Rattus norvegicus | |
0.03 | - |
CMP | - |
Rattus norvegicus | |
0.04 | - |
UMP | - |
Rattus norvegicus | |
0.053 | - |
UMP | - |
Rattus norvegicus | |
0.98 | - |
CMP | - |
Rattus norvegicus | |
2.77 | - |
dCMP | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for phosphorylation of CMP, UMP and dCMP by either ATP or dCTP | Rattus norvegicus | |
Mn2+ | with CMP as phosphate donor, Mn2+, Ni2+ and Ca2+ are able to substitute for Mg2+, 100%, Mn2+, 42%, Ni2+, 15% and Ca2+, 13% | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
30.17 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + CMP | - |
Rattus norvegicus | ADP + CDP | - |
? | |
ATP + dCMP | - |
Rattus norvegicus | ADP + dCDP | - |
? | |
ATP + UMP | - |
Rattus norvegicus | ADP + UDP | - |
? | |
CTP + CMP | - |
Rattus norvegicus | CDP + CDP | - |
? | |
dATP + CMP | - |
Rattus norvegicus | dADP + CDP | - |
? | |
dATP + dCMP | - |
Rattus norvegicus | dADP + dCDP | - |
? | |
dATP + UMP | - |
Rattus norvegicus | dADP + ADP | - |
? | |
dCTP + CMP | - |
Rattus norvegicus | dCDP + CDP | - |
? | |
dGTP + CMP | - |
Rattus norvegicus | dGDP + CDP | - |
? | |
dTTP + CMP | - |
Rattus norvegicus | dTDP + CDP | - |
? | |
dUTP + CMP | - |
Rattus norvegicus | dUDP + CDP | - |
? | |
GTP + CMP | - |
Rattus norvegicus | GDP + CDP | - |
? | |
ITP + CMP | - |
Rattus norvegicus | IDP + CDP | - |
? | |
ITP + UMP | - |
Rattus norvegicus | IDP + UDP | - |
? | |
UTP + CMP | - |
Rattus norvegicus | UDP + CDP | - |
? | |
XTP + CMP | - |
Rattus norvegicus | XDP + CDP | - |
? |