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Literature summary for 2.7.4.1 extracted from

  • Peng, L.; Jiang, Q.; Pan, J.; Deng, C.; Yu, J.; Wu, X.; Huang, S.; Deng, X.
    Involvement of polyphosphate kinase in virulence and stress tolerance of uropathogenic Proteus mirabilis (2016), Med. Microbiol. Immunol., 205, 97-109.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.1

Cloned(Commentary)

Cloned (Comment) Organism
gene ppk, subcloning in Escherichia coli strain TOP10 Proteus mirabilis

Protein Variants

Protein Variants Comment Organism
additional information construction of a ppk gene encoding the PPK insertional mutant in Proteus mirabilis strain HI4320 Proteus mirabilis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Proteus mirabilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (phosphate)n Proteus mirabilis
-
 ADP + (phosphate)n+1
-
 r
ATP + (phosphate)n Proteus mirabilis HI4320
-
 ADP + (phosphate)n+1
-
 r

Organism

Organism UniProt Comment Textmining
Proteus mirabilis B4EY92 gene ppk
-
Proteus mirabilis HI4320 B4EY92 gene ppk
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (phosphate)n
-
 Proteus mirabilis ADP + (phosphate)n+1
-
 r
ATP + (phosphate)n
-
 Proteus mirabilis HI4320 ADP + (phosphate)n+1
-
 r

Synonyms

Synonyms Comment Organism
PPK
-
 Proteus mirabilis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Proteus mirabilis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Proteus mirabilis

General Information

General Information Comment Organism
malfunction the ppk-deficient mutant is deficient in resistance to oxidative, hyperosmotic and heat stress. The swarming and biofilm formation abilities of Proteus mirabilis are also attenuated after the ppk interruption. Negative phenotypes of the ppk mutant can be restored by ppk gene complementation Proteus mirabilis
physiological function enzyme PPK is an important regulator and plays a crucial role in stress tolerance and virulence in uropathogenic Proteus mirabilis, overview. Gene ppk is required for Proteus mirabilis to invade the bladder Proteus mirabilis