Application | Comment | Organism |
---|---|---|
drug development | enzyme I, EI, of the phosphoenolpyruvate phosphotransferase system isa drug target to develop antimicrobial agents, xanthone derivatives have high potential to be developed as antibiotics | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4,5,6-triacetyloxy-9-oxoxanthen-3-yl)acetate | - |
Escherichia coli | |
1,3,5-trihydroxy-2,4-bis(3-methylbut-2-enyl)xanthen-9-one | - |
Escherichia coli | |
1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | - |
Escherichia coli | |
1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | - |
Escherichia coli | |
1,3-bis(2-oxopropoxy)-9H-xanthen-9-one | - |
Escherichia coli | |
1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | - |
Escherichia coli | |
2,7-bis(2-aminoethoxy)xanthen-9-one | - |
Escherichia coli | |
2,8-dihydroxy-1,6-dimethoxyxanthen-9-one | - |
Escherichia coli | |
2-[3-(prop-2-enylamino)propoxy]xanthen-9-one | - |
Escherichia coli | |
5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxochromen-3-yl)-2,3-dihydroxy-9-oxoxanthene-1-carboxylic acid | - |
Escherichia coli | |
6-chloro-2-(methylaminomethyl)xanthen-9-one | - |
Escherichia coli | |
methyl 2-((3-[(1-methoxy-1-oxopropan-2-yl)oxy]-9-oxo-9H-xanthen-1-yl)oxy)propanoate | - |
Escherichia coli | |
methyl 4-([(1-hydroxy-9-oxo-9H-xanthen-3-yl)oxy]methyl)benzoate | - |
Escherichia coli | |
additional information | enzyme-inhibitor molecular docking of the ligand molecule, xanthone derivative ZINC14764604 or (4,5,6-triacetyloxy-9-oxoxanthen-3-yl)acetate, with the EI-HPr (histidine-containing phosphoryl carrier protein) complex, PDB ID 3EZA, and structure modelling, overview. Residues His189 of EI and His15 of HPr are involved in binding | Escherichia coli | |
propan-2-yl,2-((9-oxo-3-[2-oxo-2-(propan-2-yloxy)ethoxy]-9H-xanthen-1-yl)oxy)acetate | - |
Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
63500 | - |
- |
Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
monomer or dimer | x * 63500, enzyme I, EI, the monomer undergoes a monomer/dimer transition and only the dimer form accepts the phosphoryl group from phosphoenolpyruvate. The crystal structure of EI, PDB ID 1ZYM, reveals a dimeric protein in which each subunit comprises three domains: a domain that binds the partner HPr, a domain that carries the phosphorylated histidine residue, and a PEP-binding domain | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
phosphoenolpyruvate-dependent phosphotransferase | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
evolution | the phosphoenolpyruvate phosphotransferase system (PTS) is ubiquitous in eubacteria and absent from eukaryotes | Escherichia coli |
malfunction | deficiency of enzyme I, EI, of the phosphoenolpyruvate phosphotransferase system in bacterial mutants lead to severe growth defects | Escherichia coli |
metabolism | the phosphoenolpyruvate phosphotransferase system consists of two phosphoryl carriers, enzyme I (EI) and the histidine-containing phosphoryl carrier protein (HPr), and several PTS transporters, catalyzing the concomitant uptake and phosphorylation of several carbohydrates | Escherichia coli |