Literature summary for 2.7.3.9 extracted from

Hurtado-Gomez, E.; Abian, O.; Munoz, F.J.; Hernaiz, M.J.; Velazquez-Campoy, A.; Neira, J.L.
Defining the epitope region of a peptide from the Streptomyces coelicolor phosphoenolpyruvate:sugar phosphotransferase system able to bind to the enzyme I (2008), Biophys. J., 95, 1336-1348.

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Activating Compound

Activating Compound	Comment	Organism	Structure
phosphoenolpyruvate	dependent on	Streptomyces coelicolor

Application

Application	Comment	Organism
drug development	the enzyme is a target for antibacterial drugs. These drugs can be obtained from peptides or protein fragments able to interfere with the first reaction of the protein cascade: the phosphorylation of the HPr by the first enzyme, the so-called enzyme enzyme I, overview	Streptomyces coelicolor

Inhibitors

Inhibitors	Comment	Organism	Structure
HPr9-30 peptide	i.e. Ac-GWAEGLHARPASIFVRAATATG-CONH2, derived from HPrsc, spanning residues Gly-9 to Ala-30	Streptomyces coelicolor
additional information	design and development of specific drugs, which can be obtained from peptides or protein fragments able to interfere with the first reaction of the protein cascade: the phosphorylation of the HPr by the first enzyme, the so-called enzyme enzyme I, overview. Interaction and binding analysis by fluorescence and circular dichroism, thermodynamic parameters, detailed overview	Streptomyces coelicolor

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Streptomyces coelicolor	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Streptomyces coelicolor	the bacterial phosphoenolpyruvate:sugar phosphotransferase system, PTS, consists of a cascade of several proteins involved in the uptake and phosphorylation of carbohydrates, and in signal transduction pathways, overview. The PTS involves a cascade of phosphoryl-transfer steps from phosphoenolpyruvate to sugar-specific enzyme II permeases via phosphointermediates of the general cytosolic non-sugar-specific phosphotransferase enzyme I and HPr	?	-	?
phosphoenolpyruvate + protein histidine	Streptomyces coelicolor	the dimeric protein enzyme I is autophosphorylated on a histidine residue by PEP, followed by phosphoryl group transfer to the histidine phosphocarrier protein, HPr, overview	pyruvate + protein phospho-L-histidine	-	?

Organism

Organism	UniProt	Comment	Textmining
Streptomyces coelicolor	Q9KZP1	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	the dimeric protein enzyme I is autophosphorylated on a histidine residue by PEP, followed by phosphoryl group transfer to the histidine phosphocarrier protein, HPr, overview	Streptomyces coelicolor

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the bacterial phosphoenolpyruvate:sugar phosphotransferase system, PTS, consists of a cascade of several proteins involved in the uptake and phosphorylation of carbohydrates, and in signal transduction pathways, overview. The PTS involves a cascade of phosphoryl-transfer steps from phosphoenolpyruvate to sugar-specific enzyme II permeases via phosphointermediates of the general cytosolic non-sugar-specific phosphotransferase enzyme I and HPr	Streptomyces coelicolor	?	-	?
phosphoenolpyruvate + protein histidine	the dimeric protein enzyme I is autophosphorylated on a histidine residue by PEP, followed by phosphoryl group transfer to the histidine phosphocarrier protein, HPr, overview	Streptomyces coelicolor	pyruvate + protein phospho-L-histidine	-	?

Synonyms

Synonyms	Comment	Organism
non-sugar-specific phosphotransferase	-	Streptomyces coelicolor
PEP:sugar PT	-	Streptomyces coelicolor
phosphoenolpyruvate:sugar phosphotransferase	-	Streptomyces coelicolor

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Release 2023.1 (January 2023)