Application | Comment | Organism |
---|---|---|
medicine | neurotoxicitiy of L-arginine in hyperargininemia may in part be due to inhibition of creatine kinase | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-arginine | treatment with single injection or for one week with daily injection of saline or L-Arg plus Nomega-nitro-L-arginine methyl ester or alpha-tocopherol plus ascorbic acid. Total and cytosolic creatine kinase activities are significantly inhibitied by L-arginine adminstration, mitochondrial enzyme activity is not affected. simultaneous injection of Nomega-nitro-L-arginine methyl ester and alpha-tocopherol plus ascorbic acid prevent inhibition | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
treatment with single injection or for one week with daily injection of saline or L-Arg plus Nomega-nitro-L-arginine methyl ester or alpha-tocopherol plus ascorbic acid | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | - |
Rattus norvegicus | - |