BRENDA - Enzyme Database
show all sequences of 2.7.2.4

Specificity of aspartokinase III from Escherichia coli and an examination of important catalytic residues

Keng, Y.F.; Viola, R.E.; Arch. Biochem. Biophys. 335, 73-81 (1996)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
lysC geneencoding for AKIII cloned into vector pTZ19U and expressed in the protease-deficient Escherichia coli BL21DE3
Escherichia coli
Inhibitors
Inhibitors
Commentary
Organism
Structure
D-aspartate beta-hydroxamate
-
Escherichia coli
D-aspartic acid 1-benzyl ester
-
Escherichia coli
Diethyl aminomalonate
-
Escherichia coli
diethyldicarbonate
-
Escherichia coli
DL-3-amino-4-hydroxybutyrate methyl ester
-
Escherichia coli
DL-3-aminobutyrate
-
Escherichia coli
L-2-aminobutyrate
competitive inhibitor
Escherichia coli
L-glutamate
-
Escherichia coli
L-glutamate gamma-methyl ester
-
Escherichia coli
L-homoserine
-
Escherichia coli
L-malate
-
Escherichia coli
L-norvaline
-
Escherichia coli
malonate
-
Escherichia coli
N-Acetylimidazole
-
Escherichia coli
N-ethylmaleimide
-
Escherichia coli
succinate
-
Escherichia coli
Tetranitromethane
-
Escherichia coli
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.6
-
L-aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
2.5
-
L-aspartate beta-benzyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
4.9
-
L-aspartate beta-methyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
5.3
-
L-aspartic acid 1-benzyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
13
-
L-aspartate beta-hydroxamate
pH 8.0, 25C, aspartokinase III
Escherichia coli
16
-
L-asparagine
pH 8.0, 25C, aspartokinase III
Escherichia coli
41
-
N-formyl-L-aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
48
-
N-acetyl-L-aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
68
-
N-Chloroacetyl-L-aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
147
-
DL-threo-3-methyl aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
184
-
L-aspartic acid amide
pH 8.0, 25C, aspartokinase III
Escherichia coli
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
2 * 50000
Escherichia coli
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
-
-
Purification (Commentary)
Commentary
Organism
aspartokinase III
Escherichia coli
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + DL-threo-3-methyl aspartate
aspartokinase III
642329
Escherichia coli
ADP + 3-methyl-4-phosphoaspartate
-
-
-
?
ATP + L-asparagine
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartate beta-hydroxamate
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartate beta-methyl ester
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartic acid 1-benzyl ester
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartic acid 4-benzyl ester
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartic acid amide
aspartokinase III
642329
Escherichia coli
ADP + 4-phospho-L-aspartic acid amide
-
-
-
?
ATP + N-acetyl-L-aspartate
aspartokinase III
642329
Escherichia coli
ADP + N-acetyl-4-phospho-L-aspartate
-
-
-
?
ATP + N-chloroacetyl-L-aspartate
aspartokinase III
642329
Escherichia coli
ADP + N-chloroacetyl-4-phospho-L-aspartate
-
-
-
?
ATP + N-formyl-L-aspartate
aspartokinase III
642329
Escherichia coli
ADP + N-formyl-4-phospho-L-aspartate
-
-
-
?
additional information
aspartokinase III, D-isomers of the derivatives of aspartic acid, including D-aspartate alpha-benzyl ester and D-aspartate beta-hydroxamate are not substrates regardless of whether the alpha- or the beta-carboxyl group is derivatized, L-cysteine sulfinate and 2-methyl-DL-aspartate are no substrates
642329
Escherichia coli
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
dimer
2 * 50000
Escherichia coli
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
9
-
Escherichia coli
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6
11
-
Escherichia coli
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
7.7
-
L-homoserine
pH 8.0, 25C, aspartokinase III
Escherichia coli
14
-
D-aspartic acid 1-benzyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
14
-
DL-3-amino-4-hydroxybutyrate methyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
28
-
L-2-aminobutyrate
pH 8.0, 25C, aspartokinase III
Escherichia coli
32
-
L-norvaline
pH 8.0, 25C, aspartokinase III
Escherichia coli
53
-
L-malate
pH 8.0, 25C, aspartokinase III
Escherichia coli
63
-
Diethyl aminomalonate
pH 8.0, 25C, aspartokinase III
Escherichia coli
82
-
L-glutamate gamma-methyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
87
-
D-aspartate beta-hydroxamate
pH 8.0, 25C, aspartokinase III
Escherichia coli
108
-
malonate
pH 8.0, 25C, aspartokinase III
Escherichia coli
128
-
L-glutamate
pH 8.0, 25C, aspartokinase III
Escherichia coli
159
-
succinate
pH 8.0, 25C, aspartokinase III
Escherichia coli
245
-
DL-3-aminobutyrate
pH 8.0, 25C, aspartokinase III
Escherichia coli
Cloned(Commentary) (protein specific)
Commentary
Organism
lysC geneencoding for AKIII cloned into vector pTZ19U and expressed in the protease-deficient Escherichia coli BL21DE3
Escherichia coli
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
D-aspartate beta-hydroxamate
-
Escherichia coli
D-aspartic acid 1-benzyl ester
-
Escherichia coli
Diethyl aminomalonate
-
Escherichia coli
diethyldicarbonate
-
Escherichia coli
DL-3-amino-4-hydroxybutyrate methyl ester
-
Escherichia coli
DL-3-aminobutyrate
-
Escherichia coli
L-2-aminobutyrate
competitive inhibitor
Escherichia coli
L-glutamate
-
Escherichia coli
L-glutamate gamma-methyl ester
-
Escherichia coli
L-homoserine
-
Escherichia coli
L-malate
-
Escherichia coli
L-norvaline
-
Escherichia coli
malonate
-
Escherichia coli
N-Acetylimidazole
-
Escherichia coli
N-ethylmaleimide
-
Escherichia coli
succinate
-
Escherichia coli
Tetranitromethane
-
Escherichia coli
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
7.7
-
L-homoserine
pH 8.0, 25C, aspartokinase III
Escherichia coli
14
-
D-aspartic acid 1-benzyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
14
-
DL-3-amino-4-hydroxybutyrate methyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
28
-
L-2-aminobutyrate
pH 8.0, 25C, aspartokinase III
Escherichia coli
32
-
L-norvaline
pH 8.0, 25C, aspartokinase III
Escherichia coli
53
-
L-malate
pH 8.0, 25C, aspartokinase III
Escherichia coli
63
-
Diethyl aminomalonate
pH 8.0, 25C, aspartokinase III
Escherichia coli
82
-
L-glutamate gamma-methyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
87
-
D-aspartate beta-hydroxamate
pH 8.0, 25C, aspartokinase III
Escherichia coli
108
-
malonate
pH 8.0, 25C, aspartokinase III
Escherichia coli
128
-
L-glutamate
pH 8.0, 25C, aspartokinase III
Escherichia coli
159
-
succinate
pH 8.0, 25C, aspartokinase III
Escherichia coli
245
-
DL-3-aminobutyrate
pH 8.0, 25C, aspartokinase III
Escherichia coli
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.6
-
L-aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
2.5
-
L-aspartate beta-benzyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
4.9
-
L-aspartate beta-methyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
5.3
-
L-aspartic acid 1-benzyl ester
pH 8.0, 25C, aspartokinase III
Escherichia coli
13
-
L-aspartate beta-hydroxamate
pH 8.0, 25C, aspartokinase III
Escherichia coli
16
-
L-asparagine
pH 8.0, 25C, aspartokinase III
Escherichia coli
41
-
N-formyl-L-aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
48
-
N-acetyl-L-aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
68
-
N-Chloroacetyl-L-aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
147
-
DL-threo-3-methyl aspartate
pH 8.0, 25C, aspartokinase III
Escherichia coli
184
-
L-aspartic acid amide
pH 8.0, 25C, aspartokinase III
Escherichia coli
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
50000
-
2 * 50000
Escherichia coli
Purification (Commentary) (protein specific)
Commentary
Organism
aspartokinase III
Escherichia coli
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + DL-threo-3-methyl aspartate
aspartokinase III
642329
Escherichia coli
ADP + 3-methyl-4-phosphoaspartate
-
-
-
?
ATP + L-asparagine
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartate beta-hydroxamate
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartate beta-methyl ester
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartic acid 1-benzyl ester
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartic acid 4-benzyl ester
aspartokinase III
642329
Escherichia coli
?
-
-
-
?
ATP + L-aspartic acid amide
aspartokinase III
642329
Escherichia coli
ADP + 4-phospho-L-aspartic acid amide
-
-
-
?
ATP + N-acetyl-L-aspartate
aspartokinase III
642329
Escherichia coli
ADP + N-acetyl-4-phospho-L-aspartate
-
-
-
?
ATP + N-chloroacetyl-L-aspartate
aspartokinase III
642329
Escherichia coli
ADP + N-chloroacetyl-4-phospho-L-aspartate
-
-
-
?
ATP + N-formyl-L-aspartate
aspartokinase III
642329
Escherichia coli
ADP + N-formyl-4-phospho-L-aspartate
-
-
-
?
additional information
aspartokinase III, D-isomers of the derivatives of aspartic acid, including D-aspartate alpha-benzyl ester and D-aspartate beta-hydroxamate are not substrates regardless of whether the alpha- or the beta-carboxyl group is derivatized, L-cysteine sulfinate and 2-methyl-DL-aspartate are no substrates
642329
Escherichia coli
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 50000
Escherichia coli
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7
9
-
Escherichia coli
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6
11
-
Escherichia coli
Other publictions for EC 2.7.2.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737413
Viswanath
-
Enhancing the activity of aspa ...
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
Am. J. Biochem. Mol. Biol.
6
33-44
2016
-
1
1
-
1
-
3
-
-
1
-
2
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
1
-
-
3
-
-
-
1
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
738802
Dong
Characterization of aspartate ...
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13869
J. Ind. Microbiol. Biotechnol.
43
873-885
2016
-
-
1
-
1
-
3
-
-
1
-
2
-
7
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
3
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
747010
Xu
-
Modification of aspartokinase ...
Escherichia coli, Escherichia coli LATR11
Biochem. Eng. J.
114
79-86
2016
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737545
Wang
Evolution of a chimeric aspart ...
Bacillus subtilis 168, Bacillus subtilis, Thermus thermophilus
Appl. Microbiol. Biotechnol.
99
8527-8536
2015
-
-
2
-
2
-
-
-
-
2
-
3
-
7
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
2
-
2
-
-
-
-
-
-
2
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
738419
Min
Characterization of Aspartate ...
Corynebacterium pekinense
Int. J. Mol. Sci.
16
28270-28284
2015
-
-
1
1
5
-
4
1
-
1
3
1
-
2
-
-
-
-
-
-
-
-
1
1
2
-
1
-
2
-
1
1
-
-
-
-
-
1
1
1
5
-
-
4
-
1
-
1
3
1
-
-
-
-
-
-
-
-
1
1
2
-
1
-
2
-
1
-
-
4
4
-
-
-
739356
Clark
Analysis of loss-of-function m ...
Arabidopsis thaliana
Plant Physiol.
168
1512-1526
2015
-
-
-
-
1
-
-
-
1
1
-
5
-
6
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
5
-
-
-
-
-
3
5
-
5
-
-
-
-
-
5
-
-
5
-
-
-
-
-
-
-
-
-
-
2
10
-
-
-
737927
Manjasetty
Crystal structure of Clostridi ...
Clostridium acetobutylicum
Biotechnol. Rep.
3
73-85
2014
-
-
1
1
-
-
2
-
-
1
-
1
-
4
-
-
1
-
-
-
-
-
2
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
2
-
-
-
1
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
4
4
-
-
-
739505
Tong
Co-expression of bacterial asp ...
Escherichia coli
PLoS ONE
9
e88310
2014
-
-
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
723793
Rastegari
-
Improvement in the production ...
Corynebacterium glutamicum
Trop. J. Pharm. Res.
12
51-56
2013
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
721208
Schuldt
Cloning, expression, purificat ...
Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
67
380-385
2011
-
-
1
1
-
-
1
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722530
Stoeveken
A specialized aspartokinase en ...
Pseudomonas stutzeri
J. Bacteriol.
193
4456-4468
2011
-
-
1
-
-
-
2
4
-
-
5
-
-
4
-
-
1
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
7
-
-
1
-
-
-
-
7
2
-
4
-
-
5
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
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1
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1
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1
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1
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1
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1
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Ferreira
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Determination of aspartate kin ...
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3
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1
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1
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2
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1
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663452
Velasco
A new mutation in the yeast as ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae HT1(pIVUts31d), Saccharomyces cerevisiae SG211
Yeast
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2005
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Conversion of feedback regulat ...
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2
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Marina
Characterization of the aspart ...
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Rognes
Transcriptional and biochemica ...
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3
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Functionally important amino a ...
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Demidov
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Additive effects of the feed-b ...
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Paris
Overproduction, purification, ...
Arabidopsis thaliana
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1
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3
1
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2
1
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2
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1
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2
-
-
-
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1
-
4
1
-
3
1
-
-
-
1
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-
2
1
2
2
-
-
-
-
-
-
-
1
-
-
-
-
-
-
654640
James
Production and characterizatio ...
Escherichia coli
Biochemistry
41
3720-3725
2002
-
-
1
-
-
-
1
2
-
-
-
1
-
2
-
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2
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2
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1
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1
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1
1
2
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1
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-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
642337
Hernando-Rico
Structure of the ask-asd opero ...
Amycolatopsis lactamdurans, Amycolatopsis lactamdurans LC411, no activity in Streptomyces akiyoshiensis
Microbiology
147
1547-1555
2001
-
-
1
-
-
-
2
-
-
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2
-
-
4
-
-
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-
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1
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1
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-
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2
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2
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642338
King
Evidence for direct interactio ...
Bradyrhizobium japonicum, Bradyrhizobium japonicum I110proC
J. Biol. Chem.
276
21311-21316
2001
-
-
1
-
-
-
-
-
-
-
-
2
-
3
-
-
1
-
-
-
-
-
2
-
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-
-
-
-
-
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1
-
-
-
-
-
-
-
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2
-
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1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642339
Kobashi
Characterization of aspartate ...
Bacillus subtilis
Biosci. Biotechnol. Biochem.
65
1391-1394
2001
-
-
1
-
-
-
2
2
-
-
1
1
-
3
-
-
1
-
-
-
1
1
2
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
2
-
2
-
-
1
1
-
-
-
1
-
-
1
1
2
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
390201
Zhang
Expression in Escherichia coli ...
Amycolatopsis mediterranei
Appl. Microbiol. Biotechnol.
54
52-58
2000
-
-
1
-
-
-
3
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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-
1
-
-
-
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3
-
2
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642335
Lugli
-
Effects of calcium, S-adenosyl ...
Oryza sativa
Plant Sci.
150
51-58
2000
3
-
-
-
-
-
2
-
-
2
-
1
-
1
-
-
1
-
-
1
-
-
2
-
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-
-
-
-
-
-
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-
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-
3
-
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-
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-
2
-
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-
2
-
1
-
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1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642332
Arevalo-Rodriguez
Mutations that cause threonine ...
Saccharomyces cerevisiae
Yeast
15
1331-1345
1999
-
-
1
-
3
-
1
4
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
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-
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-
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-
1
-
-
3
-
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1
-
4
-
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-
1
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-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642333
Kobashi
Kinetic and mutation analyses ...
Thermus thermophilus
J. Biosci. Bioeng.
87
739-745
1999
1
-
1
-
27
-
-
49
-
1
2
1
-
3
-
-
1
-
-
-
1
1
2
1
-
-
-
24
-
-
-
-
-
-
-
1
-
1
-
-
27
-
-
-
-
49
-
1
2
1
-
-
-
1
-
-
1
1
2
1
-
-
-
24
-
-
-
-
-
-
-
-
-
-
642334
Rao
Analysis of photocontrol of as ...
Hordeum vulgare
Biochem. Mol. Biol. Int.
47
347-360
1999
-
-
-
-
-
-
1
-
1
1
-
1
-
3
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
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-
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-
-
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-
1
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1
1
-
1
-
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-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642331
Kochhar
Subunit structure of lysine se ...
Spinacia oleracea
Biochem. Mol. Biol. Int.
44
795-806
1998
1
-
-
-
-
-
3
-
-
1
3
-
-
2
-
-
1
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
-
1
3
-
-
-
-
1
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642330
Heremans
A mutant of Arabidopsis thalia ...
Arabidopsis thaliana
Biochem. Genet.
35
139-153
1997
-
-
-
-
-
-
2
-
-
-
-
-
-
3
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
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-
-
-
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-
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-
-
-
-
-
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2
-
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-
-
-
-
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-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642329
Keng
Specificity of aspartokinase I ...
Escherichia coli
Arch. Biochem. Biophys.
335
73-81
1996
-
-
1
-
-
-
17
11
-
-
1
-
-
3
-
-
1
-
-
-
-
-
11
1
-
-
-
-
1
1
-
-
13
-
-
-
-
1
-
-
-
-
-
17
13
11
-
-
1
-
-
-
-
1
-
-
-
-
11
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
642328
Jetten
Effect of different levels of ...
Corynebacterium flavescens, Corynebacterium flavescens N13, Corynebacterium glutamicum
Appl. Microbiol. Biotechnol.
43
76-82
1995
-
-
2
-
1
-
1
-
-
-
2
1
-
4
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642327
Azevedo
-
Aspartate kinase regulation in ...
Zea mays
Phytochemistry
31
3731-3734
1992
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
1
-
-
2
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
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-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642326
Dotson
Kinetic studies of lysine-sens ...
Zea mays
Plant Physiol.
93
98-104
1990
-
-
-
-
-
-
1
2
-
1
5
1
-
2
-
-
1
-
-
2
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
1
5
1
-
-
-
1
-
2
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
642325
Dotson
Purification and characterizat ...
Zea mays
Plant Physiol.
91
1602-1608
1989
-
-
-
-
-
-
2
-
1
-
4
1
-
2
-
-
1
-
-
1
1
3
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
4
1
-
-
-
1
-
1
1
3
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
642324
Relton
-
Physical and kinetic propertie ...
Daucus carota
Biochim. Biophys. Acta
953
48-60
1988
1
-
-
-
-
1
7
2
-
1
6
-
-
1
-
-
1
-
-
1
-
2
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
-
-
1
-
7
-
2
-
1
6
-
-
-
-
1
-
1
-
2
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
642323
Kochhar
-
Isolation, characterization an ...
Spinacia oleracea
Biochim. Biophys. Acta
880
220-225
1986
1
-
-
-
-
-
3
3
-
1
2
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
3
-
1
2
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642322
McCarron
Aspartokinase of Streptococcus ...
Streptococcus mutans, Streptococcus mutans BHT
J. Bacteriol.
134
483-491
1978
1
-
-
-
-
1
1
2
-
-
2
-
-
4
-
-
1
-
-
-
1
2
2
1
1
-
2
-
1
-
1
-
1
-
-
1
-
-
-
-
-
1
-
1
1
2
-
-
2
-
-
-
-
1
-
-
1
2
2
1
1
-
2
-
1
-
1
-
-
-
-
-
-
-
642319
Moir
Properties and subunit structu ...
Bacillus subtilis, Bacillus subtilis VB217
J. Biol. Chem.
252
4648-4654
1977
-
-
-
-
-
-
3
2
-
-
3
2
-
3
-
-
1
-
1
-
1
1
4
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
3
1
2
-
-
3
2
-
-
-
1
1
-
1
1
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642320
Saiki
-
Aspartokinase of an extreme th ...
Thermus thermophilus, Thermus thermophilus AT-62
Agric. Biol. Chem.
41
1651-1655
1977
-
-
-
-
-
-
1
-
-
-
-
2
-
5
-
-
1
-
-
-
1
-
2
-
1
1
1
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
1
-
-
1
-
2
-
1
1
1
-
1
1
1
-
-
-
-
-
-
-
642321
Shewry
Properties and regulation of a ...
Hordeum vulgare
Plant Physiol.
59
69-73
1977
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642318
Hitchcock
Lysine- and lysine-plus-threon ...
Brevibacillus brevis
Biochim. Biophys. Acta
445
350-363
1976
-
-
-
-
-
1
1
-
-
-
2
1
-
3
-
-
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
2
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642317
Dawson Funkhouser
Kinetic and molecular properti ...
Escherichia coli, Escherichia coli B / ATCC 11303
J. Biol. Chem.
249
5478-5484
1974
-
-
-
-
-
-
1
-
-
-
2
2
-
177
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
2
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642312
Biswas
Multivalent feedback inhibitio ...
Paenibacillus polymyxa, Paenibacillus polymyxa 63 / ATCC 25901
J. Biol. Chem.
248
2894-2900
1973
-
-
-
-
-
-
2
-
-
-
2
2
1
3
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
2
1
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642313
Dungan
Concerted feedback inhibition. ...
Pseudomonas fluorescens
J. Biol. Chem.
248
8534-8540
1973
3
-
-
-
-
-
4
-
-
3
3
1
-
3
-
-
1
-
-
-
1
-
3
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
4
-
-
-
3
3
1
-
-
-
1
-
-
1
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642314
Truffa-Bachi
-
Microbial aspartokinases ...
Azotobacter sp., Bacillus cereus, Bacillus licheniformis, Bacillus subtilis, Brevibacterium flavum, Corynebacterium glutamicum, Escherichia coli, Geobacillus stearothermophilus, Neurospora crassa, no activity in Edwardsiella sp., no activity in Providencia sp., Paenibacillus polymyxa, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas putida, Rhodobacter capsulatus, Rhodobacter sphaeroides, Rhodocyclus tenuis, Rhodospirillum rubrum, Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
8
509-553
1973
2
-
-
-
-
2
29
14
-
13
19
11
-
21
-
-
5
-
-
-
-
3
19
5
1
-
-
3
1
2
-
-
-
-
-
2
-
-
-
-
-
2
-
29
-
14
-
13
19
11
-
-
-
5
-
-
-
3
19
5
1
-
-
3
1
2
-
-
-
-
-
-
-
-
642315
Wong
Aspartokinase from wheat germ ...
Triticum aestivum
Plant Physiol.
51
322-326
1973
-
-
-
-
-
1
6
4
-
3
-
1
-
2
-
-
1
-
-
1
-
2
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
6
-
4
-
3
-
1
-
-
-
1
-
1
-
2
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
642316
Wong
Aspartokinase in Lenna minor L ...
Lemna minor
Plant Physiol.
51
327-331
1973
-
-
-
-
-
-
2
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
642310
Starnes
Threonine-sensitive aspartokin ...
Escherichia coli, Escherichia coli ATCC 9723
Biochemistry
11
677-687
1972
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642311
Veron
The threonine-sensitive homose ...
Escherichia coli
Eur. J. Biochem.
28
520-527
1972
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642309
Kuramitsu
Catalytic and regulatory prope ...
Geobacillus stearothermophilus
Arch. Biochem. Biophys.
147
683-691
1971
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642308
Paulus
Multivalent feedback inhibitio ...
Paenibacillus polymyxa
J. Biol. Chem.
242
4980-4986
1967
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642307
Black
-
Conversion of aspartic acid to ...
Saccharomyces cerevisiae
Methods Enzymol.
5
820-827
1962
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