Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the KH-type splicing regulatory protein, KSRP, serves as a decay-promoting factor for Pgk2 mRNA in male germ cells. KSRP binds to to a 93-nt sequence (the F1 region) of the 3'-UTR of the Pgk2 mRNA and destabilizes Pgk2 mRNA constructs in testis extracts and in transfected cells. Destabilization of Pgk2 mRNA occurs when t-KSRP and the Pgk2 mRNA-stabilizing protein, polypyrimidine tract binding protein 2 (PTBP2), are present together in complexes bound to the 3'-UTR of Pgk2 mRNA | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
germ cell | Pgk2 mRNA accumulates in postmeiotic germ cells | Mus musculus | - |
spermatid | - |
Mus musculus | - |
spermatocyte | in early meiosis | Mus musculus | - |
testis | similar levels of Pgk2 mRNA transcription in nuclei isolated from the testes of prepuberal (17 day old) and adult mice | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
PGK2 | - |
Mus musculus |
phosphoglycerate kinase 2 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | in the cytoplasm of early meiotic spermatocytes, t-KSRP promotes the decay of Pgk2 mRNA | down |
Mus musculus | Pgk2 mRNA is first detectable in early meiosis in spermatocytes and increases dramatically in spermatids. Decline of t-KSRP in late meiosis and increase of PTBP2 are concomitant with the increase in Pgk2 mRNA levels | up |