Protein Variants | Comment | Organism |
---|---|---|
E192A | kcat/Km for ATP is 11.7fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 58.6fold lower than wild-type value | Homo sapiens |
F165A | kcat/Km for ATP is 23fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 60.7fold lower than wild-type value | Homo sapiens |
F196A | kcat/Km for ATP is 4.2fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 19.3fold lower than wild-type value | Homo sapiens |
S392A | kcat/Km for ATP is 1.03fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 9.4fold lower than wild-type value | Homo sapiens |
S392A/T393A | kcat/Km for ATP is 304fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 1717fold lower than wild-type value | Homo sapiens |
S398A | kcat/Km for ATP is 1.13fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 5.3fold lower than wild-type value | Homo sapiens |
T393A | kcat/Km for ATP is 113fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 288fold lower than wild-type value | Homo sapiens |
T393del | kcat/Km for ATP is 14615fold lower than wild-type enzyme, kcat/3-phosphoglycerate is 27869fold lower than wild-type value | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
3-phospho-D-glyceroyl phosphate | wild-type enzyme | Homo sapiens | |
0.0091 | - |
3-phospho-D-glyceroyl phosphate | mutant enzyme E192A | Homo sapiens | |
0.01 | - |
3-phospho-D-glyceroyl phosphate | mutant enzyme T393A | Homo sapiens | |
0.017 | - |
3-phospho-D-glyceroyl phosphate | mutant enzyme F165A | Homo sapiens | |
0.03 | - |
ATP | mutant enzyme S398A | Homo sapiens | |
0.05 | - |
3-phospho-D-glycerate | wild-type enzyme | Homo sapiens | |
0.062 | - |
3-phospho-D-glycerate | mutant enzyme S398A | Homo sapiens | |
0.078 | - |
ATP | mutant enzyme S392A | Homo sapiens | |
0.09 | - |
ADP | mutant enzyme E192A | Homo sapiens | |
0.1 | - |
ADP | mutant enzyme T393A | Homo sapiens | |
0.11 | - |
ATP | wild-type enzyme | Homo sapiens | |
0.11 | - |
3-phospho-D-glycerate | mutant enzyme T393del | Homo sapiens | |
0.12 | - |
ADP | wild-type enzyme | Homo sapiens | |
0.12 | - |
ADP | mutant enzyme F165A | Homo sapiens | |
0.13 | - |
ATP | mutant enzyme T393del | Homo sapiens | |
0.24 | - |
ATP | mutant enzyme E192A | Homo sapiens | |
0.32 | - |
3-phospho-D-glycerate | mutant enzyme S392A | Homo sapiens | |
0.33 | - |
ATP | mutant enzyme F196A | Homo sapiens | |
0.53 | - |
3-phospho-D-glycerate | mutant enzyme E192A | Homo sapiens | |
0.66 | - |
ATP | mutant enzyme S392A/T393A | Homo sapiens | |
0.69 | - |
3-phospho-D-glycerate | mutant enzyme F196A | Homo sapiens | |
0.83 | - |
ATP | mutant enzyme F165A | Homo sapiens | |
0.86 | - |
ATP | mutant enzyme T393A | Homo sapiens | |
0.95 | - |
3-phospho-D-glycerate | mutant enzyme F165A | Homo sapiens | |
0.99 | - |
3-phospho-D-glycerate | mutant enzyme T393A | Homo sapiens | |
1.66 | - |
3-phospho-D-glycerate | mutant enzyme S392A/T393A | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + 3-phospho-D-glyceroyl phosphate | - |
Homo sapiens | ATP + 3-phospho-D-glycerate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-phosphoglycerate kinase | - |
Homo sapiens |
hPGK | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.067 | - |
ATP | mutant enzyme T393del | Homo sapiens | |
0.067 | - |
3-phospho-D-glycerate | mutant enzyme T393del | Homo sapiens | |
16.4 | - |
ATP | mutant enzyme S392A/T393A | Homo sapiens | |
16.4 | - |
3-phospho-D-glycerate | mutant enzyme S392A/T393A | Homo sapiens | |
58 | - |
ATP | mutant enzyme T393A | Homo sapiens | |
58 | - |
3-phospho-D-glycerate | mutant enzyme T393A | Homo sapiens | |
155 | - |
ATP | mutant enzyme E192A | Homo sapiens | |
155 | - |
3-phospho-D-glycerate | mutant enzyme E192A | Homo sapiens | |
200 | - |
ATP | mutant enzyme S398A | Homo sapiens | |
200 | - |
3-phospho-D-glycerate | mutant enzyme S398A | Homo sapiens | |
250 | - |
ADP | mutant enzyme T393A | Homo sapiens | |
250 | - |
3-phospho-D-glyceroyl phosphate | mutant enzyme T393A | Homo sapiens | |
270 | - |
ATP | mutant enzyme F165A | Homo sapiens | |
270 | - |
3-phospho-D-glycerate | mutant enzyme F165A | Homo sapiens | |
575 | - |
ATP | mutant enzyme S392A | Homo sapiens | |
575 | - |
3-phospho-D-glycerate | mutant enzyme S392A | Homo sapiens | |
610 | - |
ATP | mutant enzyme F196A | Homo sapiens | |
610 | - |
3-phospho-D-glycerate | mutant enzyme F196A | Homo sapiens | |
833 | - |
ATP | wild-type enzyme | Homo sapiens | |
833 | - |
3-phospho-D-glycerate | wild-type enzyme | Homo sapiens | |
1130 | - |
ADP | mutant enzyme E192A | Homo sapiens | |
1130 | - |
3-phospho-D-glyceroyl phosphate | mutant enzyme E192A | Homo sapiens | |
1170 | - |
ADP | mutant enzyme F165A | Homo sapiens | |
1170 | - |
3-phospho-D-glyceroyl phosphate | mutant enzyme F165A | Homo sapiens | |
2630 | - |
ADP | wild-type enzyme | Homo sapiens | |
2630 | - |
3-phospho-D-glyceroyl phosphate | wild-type enzyme | Homo sapiens |