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Literature summary for 2.7.2.3 extracted from
- The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine (2007), Mol. Pharmacol., 72, 536-544.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | hypoxic treatment induces the protein expression of PGK 3fold, induction of HIF-1alpha by addition of 0.5 mM dimethyloxallyl glycine increases PGK expression under normoxic conditions | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | overexpression or down-regulation of PGK affects the cytotoxicity of beta-L-dioxolane-cytidine, which is under clinical trials for treating cancer, but not that of beta-D-2',2'-difluorodeoxycytidine under normoxic conditions, overexpression of PGK does not further increase the cytotoxicity of beta-L-dioxolane-cytidine under hypoxic conditions | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of PGK using transient transfection of pcDNA5-PGK | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| shRNA | knockdown of PGK, followed by a reduced cytotoxicity of beta-L-dioxolane-cytidine approximately 1.4- and 1.8fold under normoxic and hypoxic conditions, respectively | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-673 cell | hypoxic treatment induces the protein expression of PGK | Homo sapiens | - |
| HEP-3B cell | - |
Homo sapiens | - |
| HEP-3B cell | hypoxic treatment induces the protein expression of PGK | Homo sapiens | - |
| Hep-G2 cell | - |
Homo sapiens | - |
| Hep-G2 cell | hypoxic treatment induces the protein expression of PGK | Homo sapiens | - |
| additional information | A-673 cell | Homo sapiens | - |
| PANC-1 cell | - |
Homo sapiens | - |
| PANC-1 cell | hypoxic treatment induces the protein expression of PGK | Homo sapiens | - |
| RKO cell | - |
Homo sapiens | - |
| RKO cell | hypoxic treatment induces the protein expression of PGK | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PGK | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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