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Literature summary for 2.7.2.3 extracted from

  • Blattner, J.; Helfert, S.; Michels, P.; Clayton, C.
    Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism (1998), Proc. Natl. Acad. Sci. USA, 95, 11596-11600.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.2.3

Cloned(Commentary)

Cloned (Comment) Organism
inducible expression of cytosolic isozyme in bloodstream parasites, toxicity depends on the expression level of active enzyme Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol in parasites grown in the gut of tsetse fly Trypanosoma brucei 5829
-
glycosome in parasites grown in mammalian bloodstream Trypanosoma brucei 20015
-
additional information the catalytically active cytosolic isozyme is toxic and lethal for bloodstream parasites Trypanosoma brucei
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + 3-phospho-D-glyceroyl phosphate Trypanosoma brucei
-
 ATP + 3-phospho-D-glycerate
-
 r

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
 glycosomal PGKA and cytosolic PGKB isozymes
-
Trypanosoma brucei
-
 from mammalian blood stream and the gut of tsetse fly
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + 3-phospho-D-glyceroyl phosphate
-
 Trypanosoma brucei ATP + 3-phospho-D-glycerate
-
 r
ATP + 3-phospho-D-glycerate
-
 Trypanosoma brucei ADP + 1,3-diphosphoglycerate
-
 r

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Trypanosoma brucei
ATP required as phosphate donor Trypanosoma brucei